The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice.
Animals
Diabetes Mellitus, Type 1
/ immunology
Insulin-Secreting Cells
/ drug effects
Interferon-gamma
/ immunology
Interleukin Receptor Common gamma Subunit
/ immunology
Janus Kinase 1
/ antagonists & inhibitors
Janus Kinase Inhibitors
/ pharmacokinetics
Male
Mice, Inbred C57BL
Mice, Inbred NOD
Signal Transduction
/ drug effects
Spleen
/ immunology
CD8+ T cell
JAK-STAT signaling pathway
cytokines
non-obese diabetic mouse
type 1 diabetes mellitus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
07
2020
accepted:
04
11
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
16
7
2021
Statut:
epublish
Résumé
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8
Identifiants
pubmed: 33343569
doi: 10.3389/fimmu.2020.588543
pmc: PMC7746546
doi:
Substances chimiques
Interleukin Receptor Common gamma Subunit
0
Janus Kinase Inhibitors
0
Interferon-gamma
82115-62-6
Janus Kinase 1
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
588543Informations de copyright
Copyright © 2020 Ge, Jhala, Fynch, Akazawa, Litwak, Pappas, Catterall, Vakil, Long, Olson, Krishnamurthy, Kay and Thomas.
Déclaration de conflit d'intérêts
At the time of the study, AL and LO were both employees of Abbvie. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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