Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
PBMC
RNAseq
pulmonary arterial hypertension
transcriptome profiling
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Historique:
received:
16
09
2020
accepted:
03
10
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
Identifiants
pubmed: 33343881
doi: 10.1177/2045894020968531
pii: 10.1177_2045894020968531
pmc: PMC7727059
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2045894020968531Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL141387
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL131993
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147187
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL123485
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007249
Pays : United States
Organisme : NHLBI NIH HHS
ID : R24 HL123767
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135807
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL125208
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150392
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136603
Pays : United States
Informations de copyright
© The Author(s) 2020.
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