Genetic factors in the pathogenesis of ameloblastoma, dentigerous cyst and odontogenic keratocyst.
Ameloblastoma
Dentigerous cyst and odontogenic keratocyst
Gene expression
Genetics
Polymorphism
miRNA expression
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
12
10
2020
revised:
28
11
2020
accepted:
11
12
2020
pubmed:
22
12
2020
medline:
22
1
2021
entrez:
21
12
2020
Statut:
ppublish
Résumé
Ameloblastoma (AB), dentigerous cyst (DC) and Odontogenic keratocyst (OKC) are odontogenic lesions with propensity to malignant transformation or local invasion. The molecular mechanisms of development of these lesions are not fully understood. However, some researches have reported dysregulation of tumor suppressor genes or oncogenes in these lesions. Down-regulation of P53 gene has been reported in AB, DC and OKC. Moreover, several long non-coding RNAs such as ENST00000512916 and KIAA0125 have been dysregulated in AB tissues. Single nucleotide polymorphisms within a variety of genes have been associated with certain types of odontogenic lesions. In the current review, we summarize the current data about the expression pattern of genes in these lesions and the observed association between genetic polymorphisms and development of these lesions.
Identifiants
pubmed: 33346102
pii: S0378-1119(20)31038-6
doi: 10.1016/j.gene.2020.145369
pii:
doi:
Substances chimiques
Genetic Markers
0
RNA, Long Noncoding
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
145369Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.