Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis in female patients.
Hair removal
Hypertrichosis
TrichoScan
capryloyl glycine
hair imaging
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
20
11
2020
received:
03
08
2020
accepted:
07
12
2020
pubmed:
22
12
2020
medline:
7
8
2021
entrez:
21
12
2020
Statut:
ppublish
Résumé
Treatment of unwanted body hair is a challenging area in cosmetic dermatology. Topical soy isoflavones and derivatives or eflornithine have been utilized in dermatocosmetology for their estrogenic and antiandrogenic activity. To evaluate the efficacy of a formulation containing capryloyl glycine 4% in decreasing hair growth on the forearms after topical application for 120 days vs placebo. A total of 69 female patients entered the study (age 37 ± 6). Hair growth was quantified using TrichoScan software on both forearms at 20-fold magnification (analyzed area 0.651 cm2). Hair density (number of hairs/cm There was a significant decrease on hair density, median, and terminal hair at the end of the treatment in the active-treated site (P < .001) as measured by TrichoScan software. Direct comparison between active and placebo-treated sites showed no significant differences at T0, but highly significant differences at T120 (P < .001). The study shows that a cosmetic formulation based on capryloyl glycine 4% is highly effective in reducing several parameters related to hair growth and hair thickness vs placebo, thus showing efficacy in the treatment of hypertrichosis.
Sections du résumé
BACKGROUND
BACKGROUND
Treatment of unwanted body hair is a challenging area in cosmetic dermatology. Topical soy isoflavones and derivatives or eflornithine have been utilized in dermatocosmetology for their estrogenic and antiandrogenic activity.
AIMS
OBJECTIVE
To evaluate the efficacy of a formulation containing capryloyl glycine 4% in decreasing hair growth on the forearms after topical application for 120 days vs placebo.
METHODS
METHODS
A total of 69 female patients entered the study (age 37 ± 6). Hair growth was quantified using TrichoScan software on both forearms at 20-fold magnification (analyzed area 0.651 cm2). Hair density (number of hairs/cm
RESULTS
RESULTS
There was a significant decrease on hair density, median, and terminal hair at the end of the treatment in the active-treated site (P < .001) as measured by TrichoScan software. Direct comparison between active and placebo-treated sites showed no significant differences at T0, but highly significant differences at T120 (P < .001).
CONCLUSIONS
CONCLUSIONS
The study shows that a cosmetic formulation based on capryloyl glycine 4% is highly effective in reducing several parameters related to hair growth and hair thickness vs placebo, thus showing efficacy in the treatment of hypertrichosis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2527-2530Subventions
Organisme : BMG Pharma, Milan
ID : partially supported
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
McKnight E. The prevalence of hirsutism in young women. Lancet. 1964;1:410-413.
Liew SH. Unwanted body hair and its removal: a review. Dermatol Surg. 1999;25(6):431-439.
Wagner RF, Tomich JM, Grande DJ. Electrolysis and thermolysis for permanent hair removal. J Am Acad Dermatol. 1985;3:441-449.
Nouri K, Vejjabhinanta V, Patel SS, Singh A. Photoepilation: a growing trend in laser-assisted cosmetic dermatology. J Cosmet Dermatol. 2008;7(1):61-67.
Kern AD, Oliveira MA, Coffino P, Hackert ML. Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. Structure. 1999;7:567-581.
Auvinen M, Paasinen A, Andersson LC, Hölttä E. Ornithine decarboxylase activity is critical for cell transformation. Nature. 1992;360:355-358.
Balfour JA, McClellan K. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-202.
Zahoor H, Noor SM, Paracha MM. Combination of intense pulse light and topical eflornithine therapy versus intense pulse light therapy alone in the treatment of idiopathic facial hirsutism: a randomized controlled trial. J Pak Med Assoc. 2019;69(7):930-933.
Farshi S, Mansouri P, Rafie F. A randomized double blind, vehicle controlled bilateral comparison study of the efficacy and safety of finasteride 0.5% solution in combination with intense pulsed light in the treatment of facial hirsutism. J Cosmet Laser Ther. 2012;14(4):193-199.
Haslam IS, Hardman JA, Paus R. Topically applied nicotinamide inhibits human hair follicle growth ex vivo. J Invest Dermatol. 2018;138(6):1420-1422.
Srivilai J, Phimnuan P, Jaisabai J, et al. Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial. Phytomedicine. 2017;25:29-38.
Seiberg M, Liu JC, Babiarz L, Sharlow E, Shapiro S. Soymilk reduces hair growth and hair follicle dimensions. Exp Dermatol. 2001;10:405-413.
Yates JE, Phifer JB, Flake D. Clinical inquiries. Do nonmedicated topicals relieve childhood eczema? J Fam Pract. 2009;58:280-281.
Miller DW, Koch SB, Yentzer BA, et al. An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial. J Drugs Dermatol. 2011;10:531-537.
Tang MB, Leong KF, Ou LS, et al. Cost-effectiveness study of pediatric atopic dermatitis in Asia: Atopiclair vs. regular emollient (AD-ATOP). J Drugs Dermatol. 2015;14:169-175.