Nrf2-A Molecular Target for Sepsis Patients in Critical Care.
Animals
Antioxidants
/ metabolism
B-Lymphocytes
/ metabolism
Carcinogenesis
Carcinogens
Dendritic Cells
/ metabolism
Granulocytes
/ metabolism
Humans
Immune System
Inflammation
Macrophages
/ metabolism
Monocytes
/ metabolism
NF-E2-Related Factor 2
/ metabolism
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species
Sepsis
/ metabolism
Signal Transduction
T-Lymphocytes
/ metabolism
antioxidant defense
detoxification
inflammation
resolution
sepsis
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
27
11
2020
revised:
13
12
2020
accepted:
15
12
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
14
9
2021
Statut:
epublish
Résumé
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive oxygen species (ROS) seems obvious. In line with this, data obtained in cell culture experiments and preclinical settings have shown that Nrf2 is important in regulating target genes that are necessary to ensure cellular redox balance. Additionally, Nrf2 is involved in the induction of phase II drug metabolizing enzymes, which are important both in degrading and converting drugs into active forms, and into putative carcinogens. Therefore, Nrf2 has also been implicated in tumorigenesis. This must be kept in mind when new therapy approaches are planned for the treatment of sepsis. Therefore, this review highlights the function of Nrf2 in sepsis with a special focus on the translation of rodent-based results into sepsis patients in the intensive care unit (ICU).
Identifiants
pubmed: 33348637
pii: biom10121688
doi: 10.3390/biom10121688
pmc: PMC7766194
pii:
doi:
Substances chimiques
Antioxidants
0
Carcinogens
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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