A Posteriori Dietary Patterns and Rheumatoid Arthritis Disease Activity: A Beneficial Role of Vegetable and Animal Unsaturated Fatty Acids.
Arthritis, Rheumatoid
/ physiopathology
Cross-Sectional Studies
Diet
/ methods
Fatty Acids, Unsaturated
/ administration & dosage
Female
Humans
Italy
Male
Meat
/ statistics & numerical data
Middle Aged
Principal Component Analysis
Reproducibility of Results
Risk Assessment
Severity of Illness Index
Vegetables
DAS28
SDAI
a posteriori dietary patterns
cross-sectional study
diet
disease activity
factor analysis
rheumatoid arthritis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
17 Dec 2020
17 Dec 2020
Historique:
received:
16
11
2020
revised:
11
12
2020
accepted:
14
12
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
3
9
2021
Statut:
epublish
Résumé
To our knowledge, no studies have investigated the relationship between a posteriori dietary patterns (DPs)-representing current dietary behavior-and disease activity in patients with rheumatoid arthritis (RA). We analyzed data from a recent Italian cross-sectional study including 365 RA patients (median age: 58.46 years, 78.63% females). Prevalent DPs were identified through principal component factor analysis on 33 nutrients. RA activity was measured according to the Disease Activity Score on 28 joints (DAS28) and the Simplified Disease Activity Index (SDAI). Single DPs were related to disease activity through linear and logistic regression models, adjusted for the remaining DPs and confounders. We identified five DPs (~80% variance explained). Among them, Vegetable unsaturated fatty acids (VUFA) and Animal unsaturated fatty acids (AUFA) DPs were inversely related to DAS28 in the overall analysis, and in the more severe or long-standing RA subgroups; the highest score reductions (VUFA: 0.81, AUFA: 0.71) were reached for the long-standing RA. The SDAI was inversely related with these DPs in subgroups only. This Italian study shows that scoring high on DPs based on unsaturated fats from either source provides independent beneficial effects of clinical relevance on RA disease activity, thus strengthening evidence on the topic.
Identifiants
pubmed: 33348651
pii: nu12123856
doi: 10.3390/nu12123856
pmc: PMC7766886
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
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