Dietary and environmental factors have opposite AhR-dependent effects on
Aging
/ genetics
Animals
Benzo(a)pyrene
/ toxicity
Caenorhabditis elegans
Caenorhabditis elegans Proteins
/ genetics
Diet
Environment
Escherichia coli
/ metabolism
Heat-Shock Response
/ genetics
Longevity
/ genetics
Mutation
Receptors, Aryl Hydrocarbon
/ genetics
Stress, Physiological
/ genetics
Tryptophan
/ metabolism
Ultraviolet Rays
/ adverse effects
C. elegans
aging
aryl hydrocarbon receptor
environment
microbiota
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
13 12 2020
13 12 2020
Historique:
received:
03
10
2020
accepted:
08
11
2020
pubmed:
23
12
2020
medline:
13
5
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
Genetic, dietary, and environmental factors concurrently shape the aging process. The aryl hydrocarbon receptor (AhR) was discovered as a dioxin-binding transcription factor involved in the metabolism of different environmental toxicants in vertebrates. Since then, the variety of pathophysiological processes regulated by the AhR has grown, ranging from immune response, metabolic pathways, and aging. Many modulators of AhR activity may impact on aging and age-associated pathologies, but, whether their effects are AhR-dependent has never been explored. Here, using
Identifiants
pubmed: 33349622
pii: 202316
doi: 10.18632/aging.202316
pmc: PMC7835051
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Receptors, Aryl Hydrocarbon
0
Benzo(a)pyrene
3417WMA06D
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-133Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
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