The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Animals
Carcinogenesis
/ genetics
Cell Differentiation
Cell Line, Tumor
Colonic Neoplasms
/ genetics
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
HEK293 Cells
Histone-Lysine N-Methyltransferase
/ metabolism
Histones
/ metabolism
Humans
Intestines
/ pathology
Lysine
/ metabolism
Methylation
Mice, Nude
Myeloid-Lymphoid Leukemia Protein
/ metabolism
Neoplastic Stem Cells
/ metabolism
Polycomb Repressive Complex 2
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Up-Regulation
/ genetics
Wnt Signaling Pathway
/ genetics
beta Catenin
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 12 2020
21 12 2020
Historique:
received:
22
07
2019
accepted:
16
11
2020
entrez:
22
12
2020
pubmed:
23
12
2020
medline:
16
1
2021
Statut:
epublish
Résumé
Wnt/β-catenin signaling is crucial for intestinal carcinogenesis and the maintenance of intestinal cancer stem cells. Here we identify the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5
Identifiants
pubmed: 33349639
doi: 10.1038/s41467-020-20222-z
pii: 10.1038/s41467-020-20222-z
pmc: PMC7752919
doi:
Substances chimiques
Histones
0
KMT2A protein, human
0
LGR5 protein, human
0
Receptors, G-Protein-Coupled
0
beta Catenin
0
Myeloid-Lymphoid Leukemia Protein
149025-06-9
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Polycomb Repressive Complex 2
EC 2.1.1.43
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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