Sensing of COVID-19 Antibodies in Seconds via Aerosol Jet Nanoprinted Reduced-Graphene-Oxide-Coated 3D Electrodes.
Aerosols
Antibodies, Viral
/ immunology
Antigens, Viral
/ immunology
Biosensing Techniques
COVID-19
/ immunology
Dielectric Spectroscopy
Electrochemical Techniques
Electrodes
Graphite
/ chemistry
Humans
Hydrogen-Ion Concentration
Nanostructures
Nanotechnology
/ methods
Printing, Three-Dimensional
Protein Domains
Spike Glycoprotein, Coronavirus
/ immunology
3D printing
3D sensors
COVID-19
antibody tests
gold nanoparticles
micropillars
pandemics
reduced graphene oxide
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
30
09
2020
revised:
11
11
2020
pubmed:
23
12
2020
medline:
2
3
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
Rapid diagnosis is critical for the treatment and prevention of diseases. An advanced nanomaterial-based biosensing platform that detects COVID-19 antibodies within seconds is reported. The biosensing platform is created by 3D nanoprinting of three-dimensional electrodes, coating the electrodes by nanoflakes of reduced-graphene-oxide (rGO), and immobilizing specific viral antigens on the rGO nanoflakes. The electrode is then integrated with a microfluidic device and used in a standard electrochemical cell. When antibodies are introduced on the electrode surface, they selectively bind with the antigens, changing the impedance of the electrical circuit which is detected via impedance spectroscopy. Antibodies to SARS-CoV-2 spike S1 protein and its receptor-binding-domain (RBD) are detected at a limit-of-detection of 2.8 × 10
Identifiants
pubmed: 33349975
doi: 10.1002/adma.202006647
pmc: PMC7883076
doi:
Substances chimiques
Aerosols
0
Antibodies, Viral
0
Antigens, Viral
0
Spike Glycoprotein, Coronavirus
0
graphene oxide
0
spike protein, SARS-CoV-2
0
Graphite
7782-42-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2006647Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
ACS Appl Mater Interfaces. 2019 Aug 14;11(32):29195-29206
pubmed: 31318522
Science. 2020 May 8;368(6491):
pubmed: 32234805
Biosens Bioelectron. 2018 Apr 15;102:189-195
pubmed: 29136590
Science. 2020 Aug 21;369(6506):1014-1018
pubmed: 32540904
Lab Chip. 2018 Jan 16;18(2):323-334
pubmed: 29242870
BMC Neurosci. 2007 Mar 20;8:22
pubmed: 17374155
J Med Virol. 2020 Sep;92(9):1518-1524
pubmed: 32104917
Talanta. 2010 May 15;81(3):754-9
pubmed: 20298849
Sensors (Basel). 2018 Jun 26;18(7):
pubmed: 29949904
Lancet. 2020 Apr 4;395(10230):1101-1102
pubmed: 32247384
Adv Mater. 2010 Oct 25;22(40):4467-72
pubmed: 20717985
Int J Infect Dis. 2020 Feb;91:264-266
pubmed: 31953166
J Pharm Anal. 2020 Apr;10(2):97-101
pubmed: 32292623
J Infect. 2020 Jul;81(1):e28-e32
pubmed: 32283141
Clin Biochem Rev. 2008 Aug;29 Suppl 1:S49-52
pubmed: 18852857
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Science. 2020 Aug 28;369(6507):1119-1123
pubmed: 32661058
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Infect Dis. 2020 Oct 1;222(9):1452-1461
pubmed: 32766833
J Clin Med. 2020 May 18;9(5):
pubmed: 32443459
Nat Biotechnol. 2020 Jul;38(7):870-874
pubmed: 32300245
Adv Mater. 2021 Feb;33(7):e2006647
pubmed: 33349975
Sci Adv. 2017 Mar 03;3(3):e1601986
pubmed: 28275733
Electrochem commun. 2020 Jul;116:106762
pubmed: 32501391
Clin Infect Dis. 2020 Jul 28;71(15):778-785
pubmed: 32198501
Lancet. 2020 Mar 28;395(10229):1015-1018
pubmed: 32197103
Adv Mater. 2020 Oct;32(40):e2004210
pubmed: 32864794
Sens Actuators B Chem. 2016 Jul;230:600-606
pubmed: 27019550
Br J Surg. 2020 Jun;107(7):785-787
pubmed: 32191340
Nat Mater. 2018 Jan;17(1):63-71
pubmed: 29115290
J Med Virol. 2021 Feb;93(2):719-725
pubmed: 32706393
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
Biosens Bioelectron. 2020 Dec 15;170:112673
pubmed: 33038584
Nat Nanotechnol. 2019 Dec;14(12):1143-1149
pubmed: 31712665
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734
pubmed: 32376634
Biosens Bioelectron. 2004 Nov 1;20(4):903-6
pubmed: 15522608
Proc Natl Acad Sci U S A. 2020 May 12;117(19):10484-10491
pubmed: 32327608
Adv Mater. 2014 Nov 5;26(41):7032-7
pubmed: 24975133
Adv Mater. 2020 Oct;32(43):e2004901
pubmed: 32924219