Occupational exposure to pesticides in female tea garden workers and adverse birth outcomes.
AChE
low birth weight
occupational pesticide exposure
placental hypoxia
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
revised:
17
10
2020
received:
13
07
2020
accepted:
16
11
2020
pubmed:
23
12
2020
medline:
14
7
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
Pesticides are globally used to eliminate pests from crops and plants. The increased use of pesticides has posed a serious threat to human health. This study evaluates the effects of pesticide exposure on pregnancy outcomes in tea garden workers (TGW). The acetylcholinesterase (AChE) activity was measured in the maternal blood, placenta, and cord blood of TGW and housewives (HWs). The placental structure and expression of hypoxia-inducible factor (HIF)-1α were also analyzed in TGW and HW groups delivering low birth weight (LBW) and normal birth weight (NBW) babies. A significantly decreased AChE activity was observed in maternal blood and cord blood in TGW as compared with HW in the LBW group. However, it did not change significantly in the NBW group (p < .05). The adjusted regression analysis of birth outcomes (birth weight, head circumference, infant's length, and ponderal index) revealed a significant and positive association with the levels of AChE activity in maternal blood, placenta, and cord blood in TGW (p < .05). The histological analysis showed significantly higher placental syncytial knots, chorangiosis, fibrinoid deposition, necrosis, and stromal fibrosis in the LBW group of TGW. Microinfarction, increased fibrinoid deposition, and atypical villi characteristics, such as mushroom-like structures, were observed during scanning electron microscopy along with increased HIF-1α expression in placental tissues of TGW exposed to pesticides. Results suggest that occupational pesticide exposure during pregnancy may decrease AChE activity and cause in utero pathological changes accompanied by an increased HIF-1α expression, which also contributes to placental insufficiency and fetal growth restriction.
Substances chimiques
GPI-Linked Proteins
0
Pesticides
0
Tea
0
ACHE protein, human
EC 3.1.1.7
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22677Subventions
Organisme : Indian Council of Medical Research
ID : 3/1/2/8/14-RCH
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
M. W. Aktar, D. Sengupta, A. Chowdhury, Interdisciplinary Toxicol. 2009, 2, 1.
C. Papiya, H. R. Tewari, M. K. Jha, J. Rural Dev. 2009, 28, 85.
N. Baruah, B. K. Medhi, N. Borah, A. M. Baruah, G. K. Saikia, J. Soil Water Conserv. 2017, 16, 347.
N. Arya, Int. J. Sci. Eng. Res. 2013, 4, 1.
S. Dutta, M. Bahadur, Toxicol. Mech. Methods 2016, 26, 627.
H. C. Cataño, E. Carranza, C. Huamaní, A. F. Hernández, Arch. Environ. Contam. Toxicol. 2008, 55, 153.
K. Soltaninejad, M. Abdollahi, Med. Sci. Monit. 2009, 15, RA75.
R. C. Gupta, Toxicology of Organophosphate and Carbamate Compounds, Academic Press, 2005.
S. Karami-Mohajeri, M. Abdollahi, Hum. Exp. Toxicol. 2011, 30, 1119.
S. Karami-Mohajeri, A. Ahmadipour, H. R. Rahimi, M. Abdollahi, Arhiv za higijenu rada i toksikologiju 2017, 68, 261.
M. Araoud, InTechOpen 2011, 191.
O. Benjaminov, E. Hoffer, U. Taitelman, J. Urbach, J. M. Brandes, Vet. Hum. Toxicol. 1992, 34, 10.
M. K. Srivastava, R. B. Raizada, Indian J. Exp. Biol. 1996, 34(4), 329.
X. Peng, H. Gao, R. Xu, H. Wang, J. Mei, C. Liu, J. Exp. Clin. Cancer Res. 2020, 39, 27.
Y. Wu, X. Chen, Q. Zhou, Q. He, J. Kang, J. Zheng, K. Wang, T. Duan, PLoS One 2014, 9, e86549.
G. Gurusubramanian, A. Rahman, M. Sarmah, S. Ray, S. Bora, J. Environ. Biol. 2008, 29, 813.
P. Borgohain, India. The Clarion 2013, 2, 129.
G. Shrestha, R. B. Thapa, J. Agric. Environ. 2015, 16, 188.
A. Barooah, Sci. Culture 2011, 77, 385.
G. L. Ellman, K. D. Courtney, V. Andres, R. M. Featherstone, Biochem. Pharmacol. 1961, 7, 88.
H. W. Chambers, J. E. Chambers, Pestic. Biochem. Physiol. 1989, 33, 125.
J. H. Waterborg, H. R. Matthews, Methods Mol. Biol. 1994, 32, 1.
S. Soni, G. Rath, C. P. Prasad, S. Salhan, S. Saxena, A. K. Jain, Anat., Histol., Embryol. 2010, 39, 426.
L. Bureau, Socio-Economic Conditions of Women Workers in Plantation Industry, Government of India, Ministry of Labour and Employment, 2009.
G. Gogoi, F. Ahmed, Indian J. Community Med. 2007, 32, 120.
G. Medhi, N. Hazarika, B. Shah, J. Mahanta, Indian J. Med. Sci. 2006, 60, 496.
R. C. Gupta, D. Milatovic, Mammalian Toxicology of Insecticides, Royal Society of Chemistry, 2012.
P. M. Reddy, G. H. Philip, Bull. Environ. Contam. Toxicol. 1994, 52, 619.
A. Szabó, J. Nemcsók, B. Asztalos, Z. Rakonczay, P. Kása, L. H. Hieu, Ecotoxicol. Environ. Saf. 1992, 23, 39.
A. F. Hernández, O. López, L. Rodrigo, F. Gil, G. Pena, J. L. Serrano, T. Parrón, J. C. Álvarez, J. A. Lorente, A. Pla, Toxicol. Lett. 2005, 159, 13.
B. Eskenazi, K. Harley, A. Bradman, E. Weltzien, N. P. Jewell, D. B. Barr, C. E. Furlong, N. T. Holland, Environ. Health Perspect. 2004, 112(10), 1116.
P. Dewan, V. Jain, P. Gupta, B. D. Banerjee, Chemosphere 2013, 90, 1704.
M. J. Lopez-Espinosa, M. Murcia, C. Iniguez, E. Vizcaino, S. Llop, J. Vioque, J. O. Grimalt, M. Rebagliato, F. Ballester, Pediatrics 2011, 128, e127.
G. S. Berkowitz, J. G. Wetmur, E. Birman-Deych, J. Obel, R. H. Lapinski, J. H. Godbold, I. R. Holzman, M. S. Wolff, Environ. Health. Perspect. 2004, 112, 388.
W. Naksen, T. Prapamontol, A. Mangklabruks, S. Chantara, P. Thavornyutikarn, N. Srinual, P. Panuwet, P. Barry Ryan, A. M. Riederer, D. B. Barr, Environ. Res. 2015, 142, 288.
M. S. Wolff, S. Engel, G. Berkowitz, S. Teitelbaum, J. Siskind, D. B. Barr, J. Wetmur, Pediatr. Res. 2007, 61, 243.
R. M. Whyatt, V. Rauh, D. B. Barr, D. E. Camann, H. F. Andrews, R. Garfinkel, L. A. Hoepner, D. Diaz, J. Dietrich, A. Reyes, D. Tang, P. L. Kinney, F. P. Perera, Environ. Health Perspect. 2004, 112, 1125.
C. Petit, M. Blangiardo, S. Richardson, F. Coquet, C. Chevrier, S. Cordier, Am. J. Epidemiol. 2012, 175, 1182.
C. A. Snijder, N. Roeleveld, E. te Velde, E. A. P. Steegers, H. Raat, A. Hofman, V. W. V. Jaddoe, A. Burdorf, Hum. Reprod. 2012, 27, 910.
P. E. Houghton, M. F. Mottola, J. H. Plust, C. L. Schachter, Can. J. Appl. Physiol. 2000, 25(6), 443.
S. N. Kumar, S. Raisuddin, K. J. Singh, B. Bastia, D. Borgohain, L. Teron, S. K. Sharma, A. K. Jain, J. Obstet. Gynaecol. Res. 2020, 46(5), 715.
A. E. P. Heazell, S. J. Moll, C. J. P. Jones, P. N. Baker, I. P. Crocker, Placenta 2007, 28, S33.
S. Z. Tomas, I. K. Prusac, D. Roje, I. Tadin, Gynecol. Obstet. Invest. 2011, 71, 250.
A. D. Garnica, W. Y. Chan, J. Am. Coll. Nutr. 1996, 15(3), 206.
W. W. Hay, Jr., Horm. Res. 1994, 42, 215.
M. Levario-Carrillo, A. Feria-Velasco, R. De Celis, E. Ramos-Martínez, L. Córdova-Fierro, F. J. Solís, Gynecol. Obstet. Invest. 2001, 52, 269.
M. E. Ridano, A. C. Racca, J. B. Flores-Martin, R. Fretes, C. L. Bandeira, L. Reyna, E. Bevilacqua, S. Genti-Raimondi, G. M. Panzetta-Dutari, Toxicol. Appl. Pharmacol. 2017, 329, 26.
B. V. R. Sastry, J. Olubadewo, R. D. Harbison, D. E. Schmidt, Biochem. Pharmacol. 1976, 25, 425.
B. Acosta-Maldonado, B. Sánchez-Ramírez, S. Reza-López, M. Levario-Carrillo, Hum. Exp. Toxicol. 2009, 28, 451.
S. S. Petersen, R. Khangura, D. Davydov, Z. Zhang, R. Sangha, Case Rep. Obstet. Gynecol. 2017, 2017, 1.
Y. Gebregzabiherher, A. Haftu, S. Weldemariam, H. Gebrehiwet, Obstet. Gynecol. Int. 2017, 2017, 2149156.
R. Tal, A. Shaish, I. Barshack, S. Polak-Charcon, A. Afek, A. Volkov, B. Feldman, C. Avivi, D. Harats, Am. J. Pathol. 2010, 177(6), 2950.
R. Tal, Biol. Reprod. 2012, 87, 134.
J. Patel, K. Landers, R. H. Mortimer, K. Richard, Placenta 2010, 31, 951.
T. L. Liao, S. C. Chen, C. R. Tzeng, S. H. Kao, Int. J. Mol. Sci. 2014, 15, 17733.
A. Dutta, G. Khramtsova, K. Brito, D. Alexander, A. Mueller, S. Chinthala, D. Adu, T. Ibigbami, J. Olamijulo, A. Odetunde, K. Adigun, L. Pruitt, I. Hurley, O. Olopade, O. Ojengbede, S. Rana, C. O. Olopade, Sci. Total Environ. 2017, 619-620, 212.
L. A. Shimoda, G. L. Semenza, Am. J. Respir. Crit. Care Med. 2011, 183, 152