Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives.
Antineoplastic Agents
/ chemical synthesis
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Cell Line, Tumor
Cholinesterase Inhibitors
/ chemical synthesis
Drug Design
Drug Screening Assays, Antitumor
Female
Glycoside Hydrolase Inhibitors
/ chemical synthesis
Humans
Kinetics
MCF-7 Cells
Male
Molecular Docking Simulation
Molecular Structure
Prostatic Neoplasms
/ pathology
Quinazolinones
/ chemical synthesis
Structure-Activity Relationship
Substrate Specificity
Cytotoxicity
Enzyme inhibition
Metronidazole
Molecular docking
Quinazolinone
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Feb 2021
15 Feb 2021
Historique:
received:
21
09
2020
revised:
12
12
2020
accepted:
15
12
2020
pubmed:
23
12
2020
medline:
15
4
2021
entrez:
22
12
2020
Statut:
ppublish
Résumé
In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase, human carbonic anhydrase I, and II. These compounds exhibited high inhibitory activities in comparison to used standard inhibitors with K
Identifiants
pubmed: 33352155
pii: S0141-8130(20)35292-2
doi: 10.1016/j.ijbiomac.2020.12.121
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Carbonic Anhydrase Inhibitors
0
Cholinesterase Inhibitors
0
Glycoside Hydrolase Inhibitors
0
Quinazolinones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-12Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.