iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer's Disease.
Alarmins
/ metabolism
Alzheimer Disease
/ etiology
Cell Movement
Disease Susceptibility
Gene Expression
Humans
Immunity, Innate
Immunologic Surveillance
Induced Pluripotent Stem Cells
/ cytology
Microglia
/ cytology
NF-kappa B
/ metabolism
Pathogen-Associated Molecular Pattern Molecules
/ metabolism
Signal Transduction
alpha7 Nicotinic Acetylcholine Receptor
/ genetics
Alzheimer’s disease
CHRFAM7A
DAMPs
NF-κB activation
PAMP
cholinergic anti-inflammatory response
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Dec 2020
18 Dec 2020
Historique:
received:
02
11
2020
revised:
08
12
2020
accepted:
15
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
17
3
2021
Statut:
epublish
Résumé
Neuroinflammation in Alzheimer's disease (AD) has been the focus for identifying targetable pathways for drug development. The role of amyloid beta (Aβ), a prototype of damage-associated molecular patterns (DAMPs), has been implicated in triggering an inflammatory response. As alpha7 nicotinic acetylcholine receptor (α7 nAChR) binds Aβ with high affinity, α7 nAChR may play a role in Aβ-induced neuroinflammation. The conundrum of how α7 nAChR as the mediator of the cholinergic anti-inflammatory response may trigger an inflammatory response has not been resolved.
Identifiants
pubmed: 33352944
pii: ijms21249668
doi: 10.3390/ijms21249668
pmc: PMC7765962
pii:
doi:
Substances chimiques
Alarmins
0
Chrna7 protein, human
0
NF-kappa B
0
Pathogen-Associated Molecular Pattern Molecules
0
alpha7 Nicotinic Acetylcholine Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001412
Pays : United States
Organisme : Alzheimer's Association
ID : AARG-16-443615
Pays : United States
Organisme : Community Foundation for Greater Buffalo
ID : Not Applicable
Organisme : Edward A. and Stephanie E. Fial Fund
ID : Not Applicable
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