Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated

CSF penetrance NTRK fusion ROS1 fusion abemaciclib entrectinib radiotherapy targeted therapies trametinib

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
18 Dec 2020
Historique:
received: 18 11 2020
revised: 15 12 2020
accepted: 16 12 2020
entrez: 23 12 2020
pubmed: 24 12 2020
medline: 24 12 2020
Statut: epublish

Résumé

Targeting oncogenic fusion-genes in pediatric high-grade gliomas (pHGG) with entrectinib has emerged as a highly promising therapeutic approach. Despite ongoing clinical studies, to date, no reports on the treatment of cerebrospinal fluid (CSF) disseminated fusion-positive pHGG exist. Moreover, clinically important information of combination with other treatment modalities such as intrathecal therapy, radiotherapy and other targeted agents is missing. We report on our clinical experience of entrectinib therapy in two CSF disseminated

Identifiants

pubmed: 33353026
pii: jpm10040290
doi: 10.3390/jpm10040290
pmc: PMC7766483
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Medical-scientific fund of the Mayor of the federal capital Vienna
ID : 19086
Organisme : Austrian Science Fund
ID : T 906-B28

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Auteurs

Lisa Mayr (L)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

Armin S Guntner (AS)

Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria.

Sibylle Madlener (S)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

Maria T Schmook (MT)

Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

Andreas Peyrl (A)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Amedeo A Azizi (AA)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Karin Dieckmann (K)

Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria.

Dominik Reisinger (D)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Natalia M Stepien (NM)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Kathrin Schramm (K)

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Anna Laemmerer (A)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

David T W Jones (DTW)

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Jonas Ecker (J)

Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.

Felix Sahm (F)

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Till Milde (T)

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.

Kristian W Pajtler (KW)

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Department of Pediatric Oncology, Hematology, and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Mirjam Blattner-Johnson (M)

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Miroslav Strbac (M)

Department of Laboratory Medicine and Pathology, Tree Top Hospital, Hulhumale 23000, Maldives.

Christian Dorfer (C)

Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

Thomas Czech (T)

Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

Dominik Kirchhofer (D)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

Lisa Gabler (L)

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

Walter Berger (W)

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.

Christine Haberler (C)

Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.

Leonhard Müllauer (L)

Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.

Wolfgang Buchberger (W)

Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria.

Irene Slavc (I)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Daniela Lötsch-Gojo (D)

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.
Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.

Johannes Gojo (J)

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.
Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Classifications MeSH