Fibronectin and Its Receptors in Hematopoiesis.
Animals
Cell Differentiation
Cell Movement
Cell Proliferation
Erythropoiesis
Fibronectins
/ physiology
Hematopoiesis
Hematopoietic Stem Cells
/ cytology
Hemolysis
Humans
Hyaluronan Receptors
/ metabolism
Integrins
/ metabolism
Mice
Myelopoiesis
Receptors, Fibronectin
/ physiology
Stem Cell Niche
Stem Cells
/ cytology
Thrombopoiesis
Toll-Like Receptor 4
/ metabolism
adhesion
fibronectin
hematopoiesis
homing
integrin
migration
myelopoiesis
thrombopoiesis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 12 2020
18 12 2020
Historique:
received:
12
11
2020
revised:
08
12
2020
accepted:
15
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
10
7
2021
Statut:
epublish
Résumé
Fibronectin is a ubiquitous extracellular matrix protein that is produced by many cell types in the bone marrow and distributed throughout it. Cells of the stem cell niche produce the various isoforms of this protein. Fibronectin not only provides the cells a scaffold to bind to, but it also modulates their behavior by binding to receptors on the adjacent hematopoietic stem cells and stromal cells. These receptors, which include integrins such as α4β1, α9β1, α4β7, α5β1, αvβ3, Toll-like receptor-4 (TLR-4), and CD44, are found on the hematopoietic stem cell. Because the knockout of fibronectin is lethal during embryonal development and because fibronectin is produced by almost all cell types in mammals, the study of its role in hematopoiesis is difficult. Nevertheless, strong and direct evidence exists for its stimulation of myelopoiesis and thrombopoiesis using in vivo models. Other reviewed effects can be deduced from the study of fibronectin receptors, which showed their activation modifies the behavior of hematopoietic stem cells. Erythropoiesis was only stimulated under hemolytic stress, and mostly late stages of lymphocytic differentiation were modulated. Because fibronectin is ubiquitously expressed, these interactions in health and disease need to be taken into account whenever any molecule is evaluated in hematopoiesis.
Identifiants
pubmed: 33353083
pii: cells9122717
doi: 10.3390/cells9122717
pmc: PMC7765895
pii:
doi:
Substances chimiques
CD44 protein, human
0
Fibronectins
0
Hyaluronan Receptors
0
Integrins
0
Receptors, Fibronectin
0
TLR4 protein, human
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Immunity. 1999 Nov;11(5):555-66
pubmed: 10591181
Scand J Gastroenterol. 2010 Mar;45(3):349-56
pubmed: 20017652
Blood. 2011 Apr 7;117(14):3770-9
pubmed: 21285437
J Biol Chem. 2006 Nov 24;281(47):36466-76
pubmed: 17015452
PLoS One. 2011;6(11):e28181
pubmed: 22140539
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9647-51
pubmed: 7568190
Blood. 2001 Apr 1;97(7):1975-81
pubmed: 11264161
J Immunol. 2011 May 1;186(9):5367-75
pubmed: 21441445
Nature. 2003 Oct 23;425(6960):841-6
pubmed: 14574413
Methods Mol Biol. 2011;750:187-96
pubmed: 21618092
Biochem Biophys Res Commun. 2006 Dec 1;350(4):1000-5
pubmed: 17045241
J Bone Miner Res. 2010 Apr;25(4):706-15
pubmed: 19821765
Br J Haematol. 1989 Aug;72(4):486-91
pubmed: 2789074
Cancer Res. 2018 Jan 1;78(1):129-142
pubmed: 29066511
Exp Hematol. 2014 May;42(5):404-409.e4
pubmed: 24463276
J Hematol Oncol. 2014 Dec 14;7:92
pubmed: 25498831
Exp Hematol. 1999 Sep;27(9):1384-96
pubmed: 10480429
J Biol Chem. 2001 Dec 14;276(50):47483-8
pubmed: 11585825
J Biol Chem. 2000 Mar 31;275(13):9410-7
pubmed: 10734086
Development. 1993 Dec;119(4):1079-91
pubmed: 8306876
J Cell Biol. 2005 Mar 28;168(7):1109-18
pubmed: 15795319
Leukemia. 2014 Sep;28(9):1851-60
pubmed: 24518205
Blood. 2014 Aug 28;124(9):1393-403
pubmed: 24990886
Dev Biol. 2007 Nov 1;311(1):11-24
pubmed: 17706958
J Biol Chem. 2008 Feb 1;283(5):2858-70
pubmed: 17967897
Exp Hematol. 2011 Feb;39(2):167-178.e4
pubmed: 20933052
Immunity. 2002 Mar;16(3):465-77
pubmed: 11911830
J Bone Miner Res. 2008 Aug;23(8):1278-86
pubmed: 18348696
J Cell Physiol. 2015 Jun;230(6):1342-51
pubmed: 25502698
Angiogenesis. 2017 Nov;20(4):519-531
pubmed: 28667352
Haematologica. 2016 Jan;101(1):26-37
pubmed: 26546504
Blood. 2009 Jul 2;114(1):49-59
pubmed: 19417209
J Clin Invest. 2005 Dec;115(12):3339-47
pubmed: 16322778
Cell Tissue Res. 2016 Aug;365(2):233-45
pubmed: 27053246
Nature. 2013 Mar 14;495(7440):231-5
pubmed: 23434755
Int J Hematol. 2001 Jul;74(1):9-17
pubmed: 11530812
Neoplasia. 2013 Aug;15(8):925-38
pubmed: 23908593
Nat Cell Biol. 2016 Jun;18(6):607-18
pubmed: 27111842
Haematologica. 2020 Mar;105(3):585-597
pubmed: 31101752
Immunity. 2000 Jun;12(6):653-63
pubmed: 10894165
Vaccine. 2012 Mar 28;30(15):2564-9
pubmed: 22326778
J Cell Biol. 2007 Jun 4;177(5):871-80
pubmed: 17548514
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9374-8
pubmed: 7692447
J Cell Sci. 2002 Jan 1;115(Pt 1):227-36
pubmed: 11801740
J Biol Chem. 2010 Mar 5;285(10):7006-15
pubmed: 20007695
Blood. 1999 Jan 1;93(1):149-56
pubmed: 9864156
Blood. 2006 Sep 15;108(6):1857-64
pubmed: 16735603
J Cell Biol. 1997 Oct 6;139(1):295-307
pubmed: 9314547
Curr Opin Cell Biol. 2008 Oct;20(5):502-7
pubmed: 18586094
Blood. 2007 Mar 15;109(6):2373-9
pubmed: 17095623
PLoS Biol. 2016 Sep 21;14(9):e1002562
pubmed: 27653627
Blood. 2004 Oct 1;104(7):2020-6
pubmed: 15161666
Am J Pathol. 2006 Aug;169(2):338-46
pubmed: 16877336
Immunity. 1999 Apr;10(4):463-71
pubmed: 10229189
Stem Cells. 2016 Aug;34(8):2263-8
pubmed: 27090359
Blood. 2008 Nov 1;112(9):3753-61
pubmed: 18552210
J Mol Med (Berl). 2016 May;94(5):567-81
pubmed: 26637426
Cold Spring Harb Perspect Biol. 2013 Jan 01;5(1):a011247
pubmed: 23284045
J Immunol. 2000 Oct 15;165(8):4667-75
pubmed: 11035110
Antioxid Redox Signal. 2018 Jul 10;29(2):191-204
pubmed: 29113449
Clin Dev Immunol. 2012;2012:836485
pubmed: 22737174
J Biol Chem. 2005 Jul 1;280(26):24690-7
pubmed: 15843371
J Immunol. 2012 Jun 15;188(12):5824-8
pubmed: 22586037
J Biol Chem. 2010 Nov 19;285(47):36255-9
pubmed: 20923762
Nature. 2005 Dec 8;438(7069):820-7
pubmed: 16341007
Immunity. 2006 Jun;24(6):801-12
pubmed: 16782035
Mol Cell Biol. 2003 Dec;23(24):9349-60
pubmed: 14645544
Cells. 2019 Aug 27;8(9):
pubmed: 31461896
Exp Hematol. 2005 Jan;33(1):94-9
pubmed: 15661402
J Immunol. 2015 Sep 15;195(6):2524-8
pubmed: 26276875
Cell Stem Cell. 2017 Aug 3;21(2):241-255.e6
pubmed: 28777945
J Biol Chem. 2002 Apr 26;277(17):14467-74
pubmed: 11839764
Blood. 2020 Jun 18;135(25):2286-2291
pubmed: 32294178
Bone Marrow Transplant. 2006 Dec;38(12):789-97
pubmed: 17086206
Nat Commun. 2016 Dec 01;7:13500
pubmed: 27905395
Blood. 1994 Sep 15;84(6):1802-11
pubmed: 7521691
Ann Hematol. 2016 Jan;95(2):173-8
pubmed: 26555286
J Cell Sci. 2009 Jan 15;122(Pt 2):159-63
pubmed: 19118207
J Exp Med. 2019 Mar 4;216(3):587-604
pubmed: 30733282
Dev Cell. 2013 Mar 11;24(5):472-85
pubmed: 23453597
Haematologica. 2009 Nov;94(11):1493-501
pubmed: 19608669
Nat Med. 2008 Feb;14(2):181-7
pubmed: 18193058
Cell Mol Immunol. 2013 Mar;10(2):103-6
pubmed: 23241902
Blood. 2012 Jan 5;119(1):83-94
pubmed: 22096247
Cell Stem Cell. 2014 Apr 3;14(4):445-459
pubmed: 24561084
Curr Opin Hematol. 2011 Jul;18(4):239-48
pubmed: 21546828
Blood. 1998 Dec 15;92(12):4612-21
pubmed: 9845527
Am J Hematol. 2018 Dec;93(12):1551-1560
pubmed: 30039550
J Exp Med. 2015 Aug 24;212(9):1415-32
pubmed: 26282877
J Biol Chem. 2005 May 13;280(19):18871-80
pubmed: 15677465
Haematologica. 2016 Jun;101(6):660-71
pubmed: 27252511
J Bone Miner Res. 2017 Jan;32(1):70-81
pubmed: 27427791
J Biol Chem. 2001 Mar 30;276(13):10229-33
pubmed: 11150311
PLoS One. 2019 Sep 30;14(9):e0222912
pubmed: 31569199
Cell. 1994 Jan 28;76(2):207-18
pubmed: 8293459
J Biol Chem. 2017 May 12;292(19):7745-7760
pubmed: 28325836
Cell. 1996 Jun 28;85(7):997-1008
pubmed: 8674127