Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.

Animals Anti-Inflammatory Agents / pharmacology Factor Xa Inhibitors / pharmacology Inflammasomes / metabolism Male Mice Mice, Inbred C57BL Myocardial Reperfusion Injury / drug therapy Myocytes, Cardiac / drug effects NF-kappa B / metabolism Protein C / pharmacology
inflammasomes inflammation myocardial infarction thrombin thrombosis

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
19 02 2021
Historique:
pubmed: 24 12 2020
medline: 2 10 2021
entrez: 23 12 2020
Statut: ppublish

Résumé

While thrombin is the key protease in thrombus formation, other coagulation proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate intracellular signaling via partially distinct receptors. To study the differential effects of fXa or fIIa (factor IIa) inhibition on gene expression and inflammation in myocardial ischemia-reperfusion injury. Mice were treated with a direct fIIa inhibitor (fIIai) or direct fXa inhibitor (fXai) at doses that induced comparable anticoagulant effects ex vivo and in vivo (tail-bleeding assay and FeCl We showed that specific inhibition of coagulation via direct oral anticoagulants had differential effects on gene expression and inflammation, despite comparable anticoagulant effects and infarct sizes. Targeting individual coagulation proteases induces specific cellular responses unrelated to their anticoagulant effect.

Identifiants

DOI: 10.1161/CIRCRESAHA.120.317219 PMID: 33353373 PMC: PMC8293866
pubmed: 33353373
doi: 10.1161/CIRCRESAHA.120.317219
pmc: PMC8293866
mid: NIHMS1657418
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Factor Xa Inhibitors 0
Inflammasomes 0
NF-kappa B 0
Protein C 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

513-529

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL142975
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007569
Pays : United States
Organisme : NHLBI NIH HHS
ID : UM1 HL120877
Pays : United States

Commentaires et corrections

Type : ErratumIn

Références

Circ Cardiovasc Genet. 2017 Jan;10(1):
pubmed: 28115490
Thromb Res. 2016 Jun;142:44-51
pubmed: 27131284
Blood. 2017 Dec 14;130(24):2664-2677
pubmed: 28882883
Cell Mol Immunol. 2016 Mar;13(2):148-59
pubmed: 26549800
J Mol Cell Cardiol. 2016 Jan;90:21-9
pubmed: 26643815
Prog Cardiovasc Dis. 2016 Mar-Apr;58(5):483-94
pubmed: 26674596
J Thromb Thrombolysis. 2018 Oct;46(3):393-398
pubmed: 30039454
Blood. 2016 Oct 27;128(17):2153-2164
pubmed: 27589872
J Thromb Haemost. 2018 Oct;16(10):1941-1952
pubmed: 30030891
J Biol Chem. 2001 Apr 6;276(14):11199-203
pubmed: 11278252
Blood. 2017 Sep 21;130(12):1445-1455
pubmed: 28687614
Cell Rep. 2019 Feb 26;26(9):2477-2493.e9
pubmed: 30811995
J Pharmacol Exp Ther. 2010 Mar;332(3):898-905
pubmed: 20008957
Blood. 2018 Jul 12;132(2):159-169
pubmed: 29866816
Pharmacol Ther. 2019 Mar;195:1-4
pubmed: 30321554
J Thromb Haemost. 2005 Aug;3(8):1800-14
pubmed: 16102047
Blood. 2019 Feb 28;133(9):906-918
pubmed: 30642917
N Engl J Med. 2010 Dec 23;363(26):2499-510
pubmed: 21128814
J Intern Med. 2011 Sep;270(3):215-23
pubmed: 21255134
Blood. 2018 Jul 12;132(2):148-158
pubmed: 29866818
Curr Opin Hematol. 2019 Jan;26(1):41-50
pubmed: 30451721
J Biol Chem. 1989 Feb 25;264(6):3352-6
pubmed: 2536746
Cell Mol Life Sci. 2014 Feb;71(4):549-74
pubmed: 23649149
Thromb Haemost. 2010 Jun;103(6):1116-27
pubmed: 20352166
Clin Appl Thromb Hemost. 2018 Mar;24(2):268-272
pubmed: 28703014
Am J Respir Crit Care Med. 2020 Jan 1;201(1):33-46
pubmed: 31498653
Lancet. 1999 Nov 6;354(9190):1646-7
pubmed: 10560702
BMJ Open. 2012 Oct 06;2(5):
pubmed: 23043126
Pharmacol Res. 2016 Nov;113(Pt A):484-489
pubmed: 27693274
Cell Commun Signal. 2013 Nov 11;11:86
pubmed: 24215724
Science. 2002 Jun 7;296(5574):1880-2
pubmed: 12052963
Sci Transl Med. 2016 Nov 30;8(367):367ra168
pubmed: 27903864
J Thromb Haemost. 2014 Jul;12(7):1054-65
pubmed: 24766850
Nucleic Acids Res. 2016 Jul 8;44(W1):W147-53
pubmed: 27190236
J Biol Chem. 2003 Jun 13;278(24):21584-91
pubmed: 12682049
Eur J Pharmacol. 2005 May 2;514(1):35-42
pubmed: 15878322
Circulation. 2009 Jun 9;119(22):2877-85
pubmed: 19470889
J Am Coll Cardiol. 2018 Jul 3;72(1):17-26
pubmed: 29957227
Thromb Haemost. 2012 Dec;108(6):1180-91
pubmed: 23052711
Nat Biotechnol. 2014 Sep;32(9):926-32
pubmed: 25150839
N Engl J Med. 2011 Sep 15;365(11):981-92
pubmed: 21870978
Biochemistry. 2011 May 31;50(21):4590-6
pubmed: 21526769
PLoS One. 2016 Jun 15;11(6):e0157471
pubmed: 27305147
J Cardiovasc Pharmacol Ther. 2015 Nov;20(6):554-62
pubmed: 25848131
Blood. 2004 Sep 15;104(6):1740-4
pubmed: 15178575
Nat Rev Cardiol. 2012 Mar 13;9(5):260-2
pubmed: 22411291
J Mol Cell Cardiol. 2005 Aug;39(2):277-83
pubmed: 16038707
Br J Pharmacol. 2014 Mar;171(5):1180-94
pubmed: 24354792
Blood. 2009 Aug 27;114(9):1968-73
pubmed: 19571314
J Exp Med. 2007 Oct 1;204(10):2439-48
pubmed: 17893198
Expert Opin Pharmacother. 2017 Jan;18(1):67-77
pubmed: 27924633
Commun Biol. 2018 Aug 6;1:104
pubmed: 30271984
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1337-44
pubmed: 16632551
Coron Artery Dis. 2013 Dec;24(8):628-35
pubmed: 24145765
Thromb Res. 2016 May;141:77-83
pubmed: 26974491
Circ Res. 2020 Feb 14;126(4):486-500
pubmed: 31859592
Int Heart J. 2014;55(2):101-5
pubmed: 24632952
Biochemistry. 2017 Jun 20;56(24):3119-3128
pubmed: 28549218
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53
pubmed: 23267072
Int J Mol Sci. 2019 Apr 10;20(7):
pubmed: 30974752
Nat Med. 2007 Nov;13(11):1349-58
pubmed: 17982464
BMC Biochem. 2013 Mar 07;14:6
pubmed: 23496873
Circulation. 2010 Sep 14;122(11 Suppl):S162-9
pubmed: 20837908
J Thromb Haemost. 2017 Jul;15(7):1273-1284
pubmed: 28671351
J Clin Invest. 2001 Aug;108(4):537-46
pubmed: 11518727
Thromb Haemost. 2016 Apr;115(4):835-43
pubmed: 26489881
J Thromb Haemost. 2009 May;7(5):851-6
pubmed: 19320827
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):460-75
pubmed: 23598708
Lancet. 2014 Mar 15;383(9921):955-62
pubmed: 24315724
Clin Pharmacol Ther. 2005 Oct;78(4):412-21
pubmed: 16198660
Blood. 2014 Sep 18;124(12):1968-75
pubmed: 24963045
Thromb Res. 2015 Sep;136(3):658-62
pubmed: 26188924
Arch Intern Med. 2012 Mar 12;172(5):397-402
pubmed: 22231617

Auteurs

Ihsan Gadi (I)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Sameen Fatima (S)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Ahmed Elwakiel (A)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Sumra Nazir (S)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Moh'd Mohanad Al-Dabet (M)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).
Medical Laboratories, Faculty of Health Sciences, American University of Madaba, Amman, Jordan (M.M.A.-D.).

Rajiv Rana (R)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Fabian Bock (F)

Medicine, Vanderbilt University Medical Center, Nashville, TN (F.B.).

Jayakumar Manoharan (J)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Dheerendra Gupta (D)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Ronald Biemann (R)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Bernhard Nieswandt (B)

Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Centre, University of Würzburg, Germany (B.N.).

Ruediger Braun-Dullaeus (R)

Clinics of Cardiology and Angiology, Otto-von-Guericke-University, Magdeburg, Germany (R.B.-D.).

Christian Besler (C)

Cardiology, Leipzig Heart Center (C.B.), University of Leipzig, Germany.

Markus Scholz (M)

Institute of Medical Informatics, Statistics and Epidemiology (M.S.), University of Leipzig, Germany.

Robert Geffers (R)

RG Genome Analytics, Helmholtz Center for Infection Research, Braunschweig, Germany (R.G.).

John H Griffin (JH)

Molecular Medicine, The Scripps Research Institute, La Jolla, CA (J.H.G.).

Charles T Esmon (CT)

Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 (C.T.E.).

Shrey Kohli (S)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Berend Isermann (B)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Khurrum Shahzad (K)

Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany (I.G., S.F., A.E., S.N., M.M.A.-D., R.R., J.M., D.G., R.B., S.K., B.I., K.S.).

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Different DOACs Control Inflammation in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Different DOACs Control Inflammation in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Anticoagulants › Antithrombiniques › Inhibiteurs du facteur Xa › Different DOACs Control Inflammation in...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Different DOACs Control Inflammation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Different DOACs Control Inflammation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Different DOACs Control Inflammation in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Lésion de reperfusion myocardique › Different DOACs Control Inflammation in...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Different DOACs Control Inflammation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Different DOACs Control Inflammation in...
questionsmedicales.fr › Facteurs biologiques › Inhibiteurs des facteurs de la coagulation sanguine › Protéine C › Different DOACs Control Inflammation in...