Multi-Component One-Pot Assisted Synthesis, Anti-bacterial Capabilities, and Scanning Electron Microscopy of Novel Corticosteroid Thiopyran.
Corticosteroid
Et3N
anti-bacterial
carbon disulphide
malononitrile
thiopyran
Journal
Current organic synthesis
ISSN: 1570-1794
Titre abrégé: Curr Org Synth
Pays: United Arab Emirates
ID NLM: 101208457
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
07
2020
revised:
24
10
2020
accepted:
26
10
2020
pubmed:
24
12
2020
medline:
26
10
2021
entrez:
23
12
2020
Statut:
ppublish
Résumé
Corticosteroids are an important group of polycyclic compounds having a wide range of pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically active compounds. Keeping in mind the wide range of applications of corticosteroids and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroids and study their biological properties. To achieve our aim, we employed a one-pot multi-component synthesis of steroidal thiopyran derivatives by the reaction of corticosteroids, malononitrile, and carbon disulphide in the presence of triethylamine as a catalyst. An array of novel thiopyran compounds was obtained with the highest product yield using Et We describe a facile one-pot multi-component synthesis of corticosteroid thiopyran derivatives, which are found to possess anti-bacterial activity. Excellent yields of the products, simple work-up, easily available starting materials, and non-chromatographic purification are some of the main advantages of this protocol.
Sections du résumé
BACKGROUND
Corticosteroids are an important group of polycyclic compounds having a wide range of pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically active compounds.
OBJECTIVE
Keeping in mind the wide range of applications of corticosteroids and thiopyran, herein we intend to develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially available corticosteroids and study their biological properties.
MATERIALS AND METHODS
To achieve our aim, we employed a one-pot multi-component synthesis of steroidal thiopyran derivatives by the reaction of corticosteroids, malononitrile, and carbon disulphide in the presence of triethylamine as a catalyst.
RESULTS AND DISCUSSION
An array of novel thiopyran compounds was obtained with the highest product yield using Et
CONCLUSION
We describe a facile one-pot multi-component synthesis of corticosteroid thiopyran derivatives, which are found to possess anti-bacterial activity. Excellent yields of the products, simple work-up, easily available starting materials, and non-chromatographic purification are some of the main advantages of this protocol.
Identifiants
pubmed: 33353535
pii: COS-EPUB-112553
doi: 10.2174/1570179417666201218164112
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Pyrans
0
Sulfhydryl Compounds
0
thiopyran
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
411-417Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.