Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages.
Animals
Aortic Diseases
/ genetics
Apoptosis
/ drug effects
Atherosclerosis
/ genetics
Autophagosomes
/ drug effects
Autophagy-Related Proteins
/ genetics
Carotid Artery Diseases
/ metabolism
Disease Models, Animal
HEK293 Cells
Hep G2 Cells
Humans
Lipoproteins, LDL
/ toxicity
Macrophages
/ drug effects
Male
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ drug effects
Mitochondrial Proteins
/ genetics
Mitophagy
/ drug effects
Phosphoproteins
/ genetics
Racemases and Epimerases
/ genetics
Reactive Oxygen Species
/ metabolism
Signal Transduction
atherosclerosis
autophagy
inflammation
macrophages
mitophagy
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
29
12
2020
medline:
2
6
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Atherosclerotic lesions are often characterized by accumulation of OxLDL (oxidized low-density lipoprotein), which is associated with vascular inflammation and lesion vulnerability to rupture. Extracellular AIBP (apolipoprotein A-I binding protein; encoded by These data suggest that intracellular AIBP is a new regulator of autophagy in macrophages. Mitochondria-localized AIBP augments mitophagy and participates in mitochondria quality control, protecting macrophages against cell death in the context of atherosclerosis.
Identifiants
pubmed: 33356389
doi: 10.1161/ATVBAHA.120.315485
pmc: PMC8105271
mid: NIHMS1654838
doi:
Substances chimiques
Autophagy-Related Proteins
0
Lipoproteins, LDL
0
Mitochondrial Proteins
0
Phosphoproteins
0
Reactive Oxygen Species
0
oxidized low density lipoprotein
0
NAXE protein, human
EC 5.1.-
Naxe protein, mouse
EC 5.1.-
Racemases and Epimerases
EC 5.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e82-e96Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL135737
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007044
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS047101
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL136275
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102432
Pays : United States
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