Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism.

Adult Blood Pressure / drug effects Eplerenone / pharmacology Female Glomerular Filtration Rate / drug effects Humans Hyperaldosteronism / drug therapy Kidney / drug effects Male Middle Aged Mineralocorticoid Receptor Antagonists / pharmacology Sex Factors Spironolactone / pharmacology
aldosterone cardiovascular disease eplerenone glomerular filtration rate mineralocorticoid receptor antagonist

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
02 2021
Historique:
pubmed: 29 12 2020
medline: 13 8 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

A higher incidence of bilateral primary aldosteronism in women is reported. Treatment of bilateral primary aldosteronism usually involves mineralocorticoid receptor antagonists. However, the impact of sex on renal outcomes is unknown. We compared renal outcomes between the sexes after mineralocorticoid receptor antagonist initiation by analyzing data obtained from 415 female and 313 male patients with bilateral primary aldosteronism who were treated with spironolactone or eplerenone in the JPAS (Japan Primary Aldosteronism Study). Over the course of 5 years, the temporal reduction in the estimated glomerular filtration rate was greater in women than in men (

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.16449 PMID: 33356395
pubmed: 33356395
doi: 10.1161/HYPERTENSIONAHA.120.16449
doi:

Substances chimiques

Mineralocorticoid Receptor Antagonists 0
Spironolactone 27O7W4T232
Eplerenone 6995V82D0B

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

537-545

Auteurs

Ryo Nakamaru (R)

From the Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan (R.N., K.Y., H.A., H.R.).

Koichi Yamamoto (K)

From the Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan (R.N., K.Y., H.A., H.R.).

Hiroshi Akasaka (H)

From the Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan (R.N., K.Y., H.A., H.R.).

Hiromi Rakugi (H)

From the Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan (R.N., K.Y., H.A., H.R.).

Isao Kurihara (I)

Department of Endocrinology, Metabolism and Nephrology, School of Medicine Keio University, Tokyo, Japan (I.K.).

Takashi Yoneda (T)

Department of Health Promotion and Medicine of the Future, Graduate School of Medical Science, Kanazawa University, Japan (T. Yoneda).

Takamasa Ichijo (T)

Department of Diabetes and Endocrinology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan (T.I.).

Takuyuki Katabami (T)

Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital, Japan (T.K.).

Mika Tsuiki (M)

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Japan (M.T., M.N.).

Norio Wada (N)

Department of Diabetes and Endocrinology, Sapporo City General Hospital, Japan (N.W.).

Tetsuya Yamada (T)

Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan (T. Yamada).

Hiroki Kobayashi (H)

Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan (H.K.).

Kouichi Tamura (K)

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Japan (K.T.).

Yoshihiro Ogawa (Y)

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.O.).

Junji Kawashima (J)

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan (J.K.).

Nobuya Inagaki (N)

Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Japan (N.I.).

Megumi Fujita (M)

Division of Nephrology and Endocrinology, University of Tokyo, Japan (M.F.).

Kenji Oki (K)

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan (K.O.).

Kohei Kamemura (K)

Department of Cardiology, Shinko Hospital, Kobe, Japan (K.K.).

Akiyo Tanabe (A)

Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Tokyo, Japan (A.T.).

Mitsuhide Naruse (M)

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Japan (M.T., M.N.).
Endocrine Center, Ijinkai Takeda General Hospital, Kyoto, Japan (M.N.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Éplérénone › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Maladies endocriniennes › Maladies des surrénales › Hypercorticisme › Hyperaldostéronisme › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Diurétiques › Diurétiques d'épargne potassique › Antagonistes des récepteurs des minéralocorticoïdes › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Sex Differences in Renal Outcomes After...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Spironolactone › Sex Differences in Renal Outcomes After...