The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.
Animals
Benzamides
/ administration & dosage
Benzyl Compounds
/ administration & dosage
Disease Models, Animal
Dyspepsia
/ drug therapy
Gastrointestinal Motility
/ drug effects
Isothiocyanates
/ adverse effects
Male
Mice, Inbred Strains
Morpholines
/ administration & dosage
Neostigmine
/ administration & dosage
Panax
Phytotherapy
Plant Extracts
/ administration & dosage
Thiazoles
/ administration & dosage
Wasabia
/ chemistry
Zanthoxylum
Zingiberaceae
(13)C-acetic acid breath test
Allyl isothiocyanate
Daikenchuto
Gastric motility
Mice
Journal
Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
05
2020
revised:
03
09
2020
accepted:
26
10
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
14
5
2021
Statut:
ppublish
Résumé
Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliable to evaluate prokinetic agents. Male ddY mice were used. Gastric motility was measured by
Identifiants
pubmed: 33357770
pii: S1347-8613(20)30104-3
doi: 10.1016/j.jphs.2020.10.006
pii:
doi:
Substances chimiques
Benzamides
0
Benzyl Compounds
0
Isothiocyanates
0
Morpholines
0
Plant Extracts
0
Thiazoles
0
dai-kenchu-to
0
Neostigmine
3982TWQ96G
itopride
81BMQ80QRL
allyl isothiocyanate
BN34FX42G3
Z 338
D42OWK5383
mosapride
I8MFJ1C0BY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122-129Informations de copyright
Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no competing interests.