Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola.
Anti-Inflammatory Agents
/ chemistry
Coriolaceae
/ chemistry
Dose-Response Relationship, Drug
Enzyme Inhibitors
/ chemistry
Fruiting Bodies, Fungal
/ chemistry
Humans
Molecular Structure
Neutrophils
/ drug effects
Pancreatic Elastase
/ antagonists & inhibitors
Structure-Activity Relationship
Triterpenes
/ chemistry
Antiinflammatory
Fomitopsidaceae
Fomitopsis pinicola
Triterpenoid
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
14
11
2020
revised:
12
12
2020
accepted:
12
12
2020
pubmed:
29
12
2020
medline:
22
9
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC
Identifiants
pubmed: 33358389
pii: S0045-2068(20)31860-5
doi: 10.1016/j.bioorg.2020.104562
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Enzyme Inhibitors
0
Triterpenes
0
Pancreatic Elastase
EC 3.4.21.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104562Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.