Mixed germ cell-sex cord stromal tumour of the testis and ovary: comparison and contrast.
Gonad
mixed germ cell-sex cord stromal tumour
ovary
testis
tumours composed of both germ cell and sex cord elements
Journal
Pathology
ISSN: 1465-3931
Titre abrégé: Pathology
Pays: England
ID NLM: 0175411
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
18
06
2020
revised:
07
10
2020
accepted:
15
10
2020
pubmed:
29
12
2020
medline:
25
2
2023
entrez:
28
12
2020
Statut:
ppublish
Résumé
Mixed germ cell-sex cord stromal tumours (MGC-SCSTs) of the testis and ovary differ significantly in their histological appearance, clinical behaviour, and molecular genetics. Until recently, the germ cells of testicular MGC-SCST were considered to be invariably histologically bland, whereas those from neoplasms that arise in the ovary have histological features characteristic of premalignancy. However, a recent histological and molecular genetic study demonstrated histological abnormalities and multiple chromosomal losses and gains in a small subset of testicular cases, thus providing the first evidence that testicular MGC-SCSTs can exceptionally show histological and molecular abnormalities. All cases of testicular MGC-SCST reported to date have been clinically benign, whereas ovarian examples are sometimes the precursor of a malignant germ cell neoplasm that can be clinically aggressive. Both genetic and epigenetic influences likely account for dissimilarities in these uncommon gonadal neoplasms.
Identifiants
pubmed: 33358757
pii: S0031-3025(20)31007-2
doi: 10.1016/j.pathol.2020.10.008
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Genetic Markers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-169Informations de copyright
Copyright © 2020 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.