EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count.
Aged
Aged, 80 and over
CD8-Positive T-Lymphocytes
/ virology
COVID-19
/ complications
DNA, Viral
/ analysis
Epstein-Barr Virus Infections
/ complications
Female
Herpesvirus 4, Human
/ genetics
Humans
Intensive Care Units
Killer Cells, Natural
/ virology
Lymphocyte Count
Lymphocyte Subsets
/ virology
Male
Middle Aged
Opportunistic Infections
Real-Time Polymerase Chain Reaction
SARS-CoV-2
Viral Load
COVID-19
EBV DNA
Lymphocyte subpopulation
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
04
11
2020
revised:
10
12
2020
accepted:
17
12
2020
pubmed:
29
12
2020
medline:
5
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity. A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry. Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p<0.05). In contrast, B cell count was significantly increased in ICU patients (p=0.0172). A correlation between reduced CD8
Identifiants
pubmed: 33359064
pii: S1201-9712(20)32575-3
doi: 10.1016/j.ijid.2020.12.051
pmc: PMC7833117
pii:
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
315-319Investigateurs
R Bruno
(R)
M Mondelli
(M)
E Brunetti
(E)
A Di Matteo
(A)
E Seminari
(E)
L Maiocchi
(L)
V Zuccaro
(V)
L Pagnucco
(L)
B Mariani
(B)
S Ludovisi
(S)
R Lissandrin
(R)
A Parisi
(A)
P Sacchi
(P)
Sfa Patruno
(S)
G Michelone
(G)
R Gulminetti
(R)
D Zanaboni
(D)
S Novati
(S)
R Maserati
(R)
P Orsolini
(P)
M Vecchia
(M)
M Sciarra
(M)
E Asperges
(E)
M Colaneri
(M)
A Di Filippo
(A)
M Sambo
(M)
S Biscarini
(S)
M Lupi
(M)
S Roda
(S)
T C Pieri
(TC)
I Gallazzi
(I)
M Sachs
(M)
P Valsecchi
(P)
S Perlini
(S)
C Alfano
(C)
M Bonzano
(M)
F Briganti
(F)
G Crescenzi
(G)
A G Falchi
(AG)
R Guarnone
(R)
B Guglielmana
(B)
E Maggi
(E)
I Martino
(I)
P Pettenazza
(P)
S Pioli di Marco
(S)
F Quaglia
(F)
A Sabena
(A)
F Salinaro
(F)
F Speciale
(F)
I Zunino
(I)
M De Lorenzo
(M)
G Secco
(G)
L Dimitry
(L)
G Cappa
(G)
I Maisak
(I)
B Chiodi
(B)
M Sciarrini
(M)
B Barcella
(B)
F Resta
(F)
L Moroni
(L)
G Vezzoni
(G)
L Scattaglia
(L)
E Boscolo
(E)
C Zattera
(C)
M F Tassi
(MF)
V Capozza
(V)
D Vignaroli
(D)
M Bazzini
(M)
G Iotti
(G)
F Mojoli
(F)
M Belliato
(M)
L Perotti
(L)
S Mongodi
(S)
G Tavazzi
(G)
G Marseglia
(G)
A Licari
(A)
I Brambilla
(I)
D Barbarini
(D)
A Bruno
(A)
P Cambieri
(P)
G Campanini
(G)
C Cavanna
(C)
G Comolli
(G)
M Corbella
(M)
R Daturi
(R)
M Furione
(M)
B Mariani
(B)
P Marone
(P)
R Maserati
(R)
E Monzillo
(E)
S Paolucci
(S)
M Parea
(M)
E Percivalle
(E)
A Piralla
(A)
F Rovida
(F)
A Sarasini
(A)
M Zavattoni
(M)
G Adzasehoun
(G)
M Ardizzone
(M)
L Bellotti
(L)
V Brunco
(V)
E Cabano
(E)
G Casali
(G)
L Capella
(L)
D Devitis
(D)
L Dossena
(L)
G Frisco
(G)
G Garbagnoli
(G)
F Gardellini
(F)
A Girello
(A)
A Guerrizio
(A)
V Landini
(V)
C Lucchelli
(C)
V Maliardi
(V)
P Piemontese
(P)
S Pezzaia
(S)
M Premoli
(M)
C Rebuffa
(C)
C Zanello
(C)
J Bagnarino
(J)
F Bergami
(F)
A Bonetti
(A)
G Caneva
(G)
I Cassaniti
(I)
A Corcione
(A)
R Di Martino
(R)
A Di Napoli
(A)
A Ferrari
(A)
G Ferrari
(G)
L Fiorina
(L)
A Gallone
(A)
F Giardina
(F)
A Girardi
(A)
A Mercato
(A)
C Merla
(C)
F Novazzi
(F)
G Ratano
(G)
B Rossi
(B)
G Saveriaempillai
(G)
I M Sciabica
(IM)
M Tallarita
(M)
E Vecchio Nepita
(E)
J Vitali
(J)
A Cerino
(A)
S Varchetta
(S)
B Oliviero
(B)
S Mantovani
(S)
D Mele
(D)
M Calvi
(M)
M Tizzoni
(M)
C Nicora
(C)
A Triarico
(A)
V Petronella
(V)
C Marena
(C)
A Muzzi
(A)
P Lago
(P)
S Cutti
(S)
V Novelli
(V)
F Comandatore
(F)
G BatistiBiffignandi
(G)
S Gaiarsa
(S)
M Rettani
(M)
C Bandi
(C)
A Ferrari
(A)
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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