Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats.
Animals
Antidepressive Agents
/ administration & dosage
Behavior, Animal
/ physiology
CA1 Region, Hippocampal
/ drug effects
Depression
/ drug therapy
Disease Models, Animal
Excitatory Amino Acid Transporter 2
/ drug effects
Glutamate-Ammonia Ligase
/ drug effects
Helplessness, Learned
Male
Nucleus Accumbens
/ drug effects
Pregnanolone
/ administration & dosage
Rats
Rats, Sprague-Dawley
Allopregnanolone (ALLO)
Depression
Glutamate transporter-1 (GLT-1)
Glutamine synthetase (GS)
Learned helplessness (LH)
Nucleus accumbens (NAc)
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
received:
23
08
2020
revised:
13
12
2020
accepted:
18
12
2020
pubmed:
29
12
2020
medline:
16
11
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Clinical studies have demonstrated that allopregnanolone (3α5α-tetrahydroprogesterone, ALLO) has antidepressant-like effects on patients with depression. Previous studies have shown alteration of the astroglial glutamate transporter-1 (GLT-1) and glutamine synthetase (GS) in depression, and ALLO is known to modulate glutamate release. The present study aimed to investigate whether astroglial GLT-1 and GS are indeed involved in the antidepressant-like effects of ALLO in learned helplessness (LH) rats, a validated animal model of depression. The results of this study showed that bilateral microinjection of ALLO into the lateral ventricles could normalize the levels of GLT-1 and GS in the nucleus accumbens (NAc) and of GS in the hippocampal CA1 region of LH rats. These results suggest a certain connection between the antidepressant-like effects of ALLO and the astroglial GLT-1/GS system of the NAc in LH rats.
Identifiants
pubmed: 33359844
pii: S0166-4328(20)30791-9
doi: 10.1016/j.bbr.2020.113092
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Excitatory Amino Acid Transporter 2
0
Slc1a2 protein, rat
0
Pregnanolone
BXO86P3XXW
Glutamate-Ammonia Ligase
EC 6.3.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113092Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.