Actin dynamics in the growth cone: a key player in axon regeneration.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
04
11
2020
revised:
20
11
2020
accepted:
23
11
2020
pubmed:
29
12
2020
medline:
14
9
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Neuronal development, maintenance and function depends on the tight regulation of cytoskeleton organization and dynamics. Following injury, adult central nervous system neurons have a limited ability to regenerate and to recapitulate their robust developmental axon growth. This decreased regenerative capacity is set by their inability to establish regeneration-competent growth cones. Growth cones are actin-enriched structures that regulate axon extension rate and direction. During neuronal development, increasing actin dynamics in the growth cone through the regulation of the activity of specific actin-binding proteins leads to increased axon elongation. Here, we will focus on recent findings showing that enhanced axon regeneration in the adult nervous system can be achieved by promoting actin dynamics, or by decreasing actomyosin contraction in the growth cone. These discoveries underscore the importance of actin organization in the growth cone as a key factor to promote axon (re)growth that should be further explored in the future.
Identifiants
pubmed: 33359956
pii: S0959-4388(20)30182-3
doi: 10.1016/j.conb.2020.11.015
pii:
doi:
Substances chimiques
Actins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-18Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.