The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs.

Cerebrospinal Fluid / metabolism Animals Liver / metabolism Glymphatic System / physiology Spinal Cord / metabolism Mice Serotonin / cerebrospinal fluid Actins / metabolism Ependyma / metabolism Subarachnoid Space / metabolism Pancreas / metabolism
5-HT2B receptors F-actin cerebrospinal fluid ependymal cells hepatic stellate cells

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

Mechanisms controlling the movement of the cerebrospinal fluid (CSF) toward peripheral nerves are poorly characterized. We found that, in addition to the foramina Magendie and Luschka for CSF flow toward the subarachnoid space and glymphatic system, CSF outflow could also occur along periaxonal spaces (termed "PAS pathway") from the spinal cord to peripheral organs, such as the liver and pancreas. When interrogating the latter route, we found that serotonin, acting through 5-HT

Identifiants

DOI: 10.1073/pnas.2400024121 PMID: 39485799
pubmed: 39485799
doi: 10.1073/pnas.2400024121
doi:

Substances chimiques

Serotonin 333DO1RDJY
Actins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2400024121

Subventions

Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32271038

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Xinyu Li (X)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0002-3344-3081

Siman Wang (S)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0002-5172-2682

Dianjun Zhang (D)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0002-0727-5504

Yuliang Feng (Y)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0001-7397-2386

Yingyu Liu (Y)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0009-0004-8053-2185

Weiyang Yu (W)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0009-0001-9623-3356

Lulu Cui (L)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0003-2133-8409

Tibor Harkany (T)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria.
Department of Neuroscience, Biomedicum, Karolinska Institutet, Solna 17165, Sweden.
ORCID: 0000-0002-6637-5900

Alexei Verkhratsky (A)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, United Kingdom.
Department of Neurosciences, University of the Basque Country, Leioa 48940, Bizkaia, Spain.
Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius LT-01102, Lithuania.
ORCID: 0000-0003-2592-9898

Maosheng Xia (M)

Department of Orthopaedics, The First Hospital, China Medical University, Shenyang 110002, China.
ORCID: 0000-0003-4829-0812

Baoman Li (B)

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Liaoning Province Key Laboratory of Forensic Bio-Evidence Sciences, China Medical University, Shenyang 110122, China.
China Medical University Centre of Forensic Investigation, Shenyang 110122, China.
ORCID: 0000-0002-3959-9570

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Liquide cérébrospinal › The periaxonal space as a conduit for...
questionsmedicales.fr › Eucaryotes › Animaux › The periaxonal space as a conduit for...
questionsmedicales.fr › Système digestif › Foie › The periaxonal space as a conduit for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Système glymphatique › The periaxonal space as a conduit for...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › The periaxonal space as a conduit for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The periaxonal space as a conduit for...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › The periaxonal space as a conduit for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › The periaxonal space as a conduit for...
questionsmedicales.fr › Tissus › Tissu nerveux › Épendyme › The periaxonal space as a conduit for...
questionsmedicales.fr › Système nerveux › Système nerveux central › Méninges › Arachnoïde › Espace sous-arachnoïdien › The periaxonal space as a conduit for...
questionsmedicales.fr › Système digestif › Pancréas › The periaxonal space as a conduit for...