Cytotoxicity and DNA interaction in a series of aryl terminated iminopyridine Pt(II) complexes.

A549 Cells Coordination Complexes / chemical synthesis Cytotoxins / chemical synthesis DNA, Neoplasm / chemistry Female HT29 Cells HeLa Cells Humans Ovarian Neoplasms / drug therapy Platinum / chemistry Pyridines / chemistry
Antiproliferative properties Cisplatin resistance DNA interaction Groove binding Iminopyridine platinum(II) complexes Intercalation

Journal

Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788

Informations de publication

Date de publication:
03 2021
Historique:
received: 15 09 2020
revised: 15 11 2020
accepted: 05 12 2020
pubmed: 29 12 2020
medline: 1 10 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

A series of iminopyridine complexes of platinum(II), bearing a flexible diethereal, aryl terminated residue, where the size of aryl group is varied from phenyl to 9-anthracenyl, was synthesized. The new complexes are soluble and stable in DMSO/H

Identifiants

DOI: 10.1016/j.jinorgbio.2020.111335 PMID: 33360320
pubmed: 33360320
pii: S0162-0134(20)30363-9
doi: 10.1016/j.jinorgbio.2020.111335
pii:
doi:

Substances chimiques

Coordination Complexes 0
Cytotoxins 0
DNA, Neoplasm 0
Pyridines 0
Platinum 49DFR088MY

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111335

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Riccardo Bondi (R)

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.

Lisa Dalla Via (L)

Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (C.I.R.C.M.S.B.), Bari, Italy; Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Via F. Marzolo 5, Padova I-35131, Italy. Electronic address: lisa.dallavia@unipd.it.

Mariafrancesca Hyeraci (M)

Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Via F. Marzolo 5, Padova I-35131, Italy.

Gioele Pagot (G)

Dipartimento di Ingegneria Industriale, Università degli Studi di Padova, Via F. Marzolo 9, Padova I-35131, Italy.

Luca Labella (L)

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy; Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (C.I.R.C.M.S.B.), Bari, Italy.

Fabio Marchetti (F)

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.

Simona Samaritani (S)

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy; Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (C.I.R.C.M.S.B.), Bari, Italy. Electronic address: simona.samaritani@unipi.it.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cytotoxines › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HT29 › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Platine › Cytotoxicity and DNA interaction in a series...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Cytotoxicity and DNA interaction in a series...