CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.
Amino Acid Substitution
Bacterial Proteins
/ genetics
Binding Sites
Calcium
/ metabolism
Calcium Signaling
Gene Expression Regulation
Genes, Reporter
Genetic Vectors
/ chemistry
Green Fluorescent Proteins
/ genetics
HEK293 Cells
Humans
Ion Channel Gating
/ genetics
Liposomes
/ chemistry
Luminescent Proteins
/ genetics
Molecular Dynamics Simulation
Mutation
Neoplasm Proteins
/ chemistry
ORAI1 Protein
/ chemistry
Patch-Clamp Techniques
Phosphatidylcholines
/ chemistry
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
Recombinant Proteins
/ chemistry
Stromal Interaction Molecule 1
/ chemistry
AND-gate
CRAC channel
Electrophysiology
Gating
Gating checkpoints
Opening-permissive conformation
Orai1
STIM1
Signal propagation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
Historique:
received:
07
08
2020
revised:
15
12
2020
accepted:
22
12
2020
pubmed:
29
12
2020
medline:
26
8
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca
Identifiants
pubmed: 33361160
pii: S0021-9258(20)00339-7
doi: 10.1074/jbc.RA120.015548
pmc: PMC7948504
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Liposomes
0
Luminescent Proteins
0
Neoplasm Proteins
0
ORAI1 Protein
0
ORAI1 protein, human
0
Phosphatidylcholines
0
Recombinant Proteins
0
STIM1 protein, human
0
Stromal Interaction Molecule 1
0
enhanced cyan fluorescent protein
0
yellow fluorescent protein, Bacteria
0
Green Fluorescent Proteins
147336-22-9
Calcium
SY7Q814VUP
1-palmitoyl-2-oleoylphosphatidylcholine
TE895536Y5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100224Subventions
Organisme : Austrian Science Fund FWF
ID : W 1250
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 30567
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 28701
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 32075
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 27641
Pays : Austria
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.
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