Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

Autoantibodies COVID-19 Humans Inflammation Interferon Type I / genetics SARS-CoV-2

Journal

Med (New York, N.Y.)
ISSN: 2666-6340
Titre abrégé: Med
Pays: United States
ID NLM: 101769215

Informations de publication

Date de publication:
18 12 2020
Historique:
entrez: 28 12 2020
pubmed: 29 12 2020
medline: 29 12 2020
Statut: ppublish

Résumé

The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

Identifiants

DOI: 10.1016/j.medj.2020.12.001 PMID: 33363283 PMC: PMC7748410
pubmed: 33363283
doi: 10.1016/j.medj.2020.12.001
pii: S2666-6340(20)30029-5
pmc: PMC7748410
doi:

Substances chimiques

Autoantibodies 0
Interferon Type I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

14-20

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI088364
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG006504
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG008956
Pays : United States

Informations de copyright

© 2020 Elsevier Inc.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Références

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Auteurs

Qian Zhang (Q)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Paul Bastard (P)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Alexandre Bolze (A)

Helix, San Mateo, CA, USA.

Emmanuelle Jouanguy (E)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Shen-Ying Zhang (SY)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Aurélie Cobat (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.

Helen C Su (HC)

Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.

Laurent Abel (L)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Jean-Laurent Casanova (JL)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.
Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.
Howard Hughes Medical Institute, New York, NY, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Life-Threatening COVID-19: Defective...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Life-Threatening COVID-19: Defective...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Life-Threatening COVID-19: Defective...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Life-Threatening COVID-19: Defective...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Life-Threatening COVID-19: Defective...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Life-Threatening COVID-19: Defective...