Corticosterone Enhances the AMPK-Mediated Immunosuppressive Phenotype of Testicular Macrophages During Uropathogenic
AMPK
Corticosterone
Fatty acid oxidation (FAO)
Orchitis
Testicular macrophage
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
07
2020
accepted:
10
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
16
6
2021
Statut:
epublish
Résumé
Testicular macrophages (TM) play a central role in maintaining testicular immune privilege and protecting spermatogenesis. Recent studies showed that their immunosuppressive properties are maintained by corticosterone in the testicular interstitial fluid, but the underlying molecular mechanisms are unknown. In this study, we treated mouse bone marrow-derived macrophages (BMDM) with corticosterone (50 ng/ml) and uncovered AMP-activated protein kinase (AMPK) activation as a critical event in M2 polarization at the phenotypic, metabolic, and cytokine production level. Primary TM exhibited remarkably similar metabolic and phenotypic features to corticosterone-treated BMDM, which were partially reversed by AMPK-inhibition. In a murine model of uropathogenic
Identifiants
pubmed: 33363533
doi: 10.3389/fimmu.2020.583276
pmc: PMC7752858
doi:
Substances chimiques
AMP-Activated Protein Kinases
EC 2.7.11.31
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
583276Informations de copyright
Copyright © 2020 Zhang, Jiang, Zhang, Zhang, Yan, Bhushan, Meinhardt, Qin and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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