Development of a human heart-sized perfusion system for metabolic imaging studies using hyperpolarized [1-
MRI
ex vivo
heart
hyperpolarization
metabolism
perfusion
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
15
09
2020
revised:
09
11
2020
accepted:
19
11
2020
pubmed:
29
12
2020
medline:
21
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Increasing worldwide demand for cardiac transplantation has spurred new developments to increase the donor pool. Normothermic preservation of heart grafts for transplantation is an emerging strategy to improve the utilization of marginal grafts. Hyperpolarized MR using metabolic tracers such as [1- Hearts from three 40-kg Danish domestic pigs were harvested and subsequently perfused in Langendorff mode under normothermic conditions, using an MR-compatible perfusion system adapted to the heart. Proton MRI and hyperpolarized [1- Hearts were perfused with whole blood for 120 min, using a dynamic contrast-enhanced perfusion experiment to verify successful myocardial perfusion. Hyperpolarized [1- We investigated the metabolic and functional status of machine-perfused porcine hearts. Utilizing hyperpolarized methodology to acquire detailed myocardial metabolic information-in combination with already established MR methods for cardiac investigation-provides a powerful tool to aid the progress of donor heart preservation.
Substances chimiques
Pyruvic Acid
8558G7RUTR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3510-3521Informations de copyright
© 2020 International Society for Magnetic Resonance in Medicine.
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