Fatal intoxication involving 4-methylpentedrone (4-MPD) in a context of chemsex.
4-Methylpentedrone (4-MPD)
Chemsex
Fatal intoxication
Forensic toxicology
New psychoactive substance (NPS)
Journal
Forensic science international
ISSN: 1872-6283
Titre abrégé: Forensic Sci Int
Pays: Ireland
ID NLM: 7902034
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
25
09
2020
revised:
07
12
2020
accepted:
10
12
2020
pubmed:
29
12
2020
medline:
9
6
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
4-methylpentedrone (4-MPD) is a new psychoactive substance (NPS) belonging to the cathinone class. We report an original case of death mainly involving 4-MPD, along with cocaine, sildenafil, bromazepam and nevirapine. The investigation data and the autopsy findings indicated fatal intoxication in a chemsex context (drug use during sex). 4-MPD concentrations were determined in peripheral blood (1285 ng/mL), cardiac blood (1128 ng/mL), urine (>10,000 ng/mL), bile (1187 ng/mL) and vitreous humor (734 and 875 ng/mL in left and right samples, respectively) by gas chromatography (GC) coupled to tandem mass spectrometry. 4-MPD metabolites were explored by GC coupled to high resolution mass spectrometry. Due to the paucity of data concerning 4-MPD, its use and effects were gathered from online user testimonies. This case illustrates the toxicity of this infrequent pentedrone derivate and confirms the significant overdose risk associated with chemsex.
Identifiants
pubmed: 33370656
pii: S0379-0738(20)30521-1
doi: 10.1016/j.forsciint.2020.110659
pii:
doi:
Substances chimiques
4-methylpentedrone
0
Alkaloids
0
Methylamines
0
Pentanones
0
Psychotropic Drugs
0
cathinone
540EI4406J
Cocaine
I5Y540LHVR
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
110659Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.