Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation.
Animals
Artemia
/ drug effects
Biofilms
/ drug effects
Biofouling
/ prevention & control
Click Chemistry
Flavonoids
/ chemical synthesis
Glycosides
/ chemical synthesis
Green Chemistry Technology
Hydrogen Bonding
Microalgae
/ drug effects
Molecular Structure
Mytilus
/ drug effects
Quantitative Structure-Activity Relationship
Roseobacter
/ drug effects
Triazoles
/ chemical synthesis
Water Microbiology
antifouling
biofouling
click chemistry
eco-friendly alternatives
flavonoids
synthesis
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
05
12
2020
revised:
19
12
2020
accepted:
21
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
18
5
2021
Statut:
epublish
Résumé
Over the last decades, antifouling coatings containing biocidal compounds as active ingredients were used to prevent biofouling, and eco-friendly alternatives are needed. Previous research from our group showed that polymethoxylated chalcones and glycosylated flavones obtained by synthesis displayed antifouling activity with low toxicity. In this work, ten new polymethoxylated flavones and chalcones were synthesized for the first time, including eight with a triazole moiety. Eight known flavones and chalcones were also synthesized and tested in order to construct a quantitative structure-activity relationship (QSAR) model for these compounds. Three different antifouling profiles were found: three compounds (
Identifiants
pubmed: 33374188
pii: md19010005
doi: 10.3390/md19010005
pmc: PMC7823860
pii:
doi:
Substances chimiques
Flavonoids
0
Glycosides
0
Triazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BTA-BTA/31422/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/SAU-PUB/28736/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/AAG-TEC/0739/2014
Organisme : North Portugal Regional Operational Programme (Norte 2020)
ID : NORTE-01-0145-FEDER-000040
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