Molecular Aspects and Prognostic Significance of Microcalcifications in Human Pathology: A Narrative Review.
Biomarkers
/ metabolism
Breast Diseases
/ metabolism
Calcinosis
/ pathology
Disease Progression
Epithelial-Mesenchymal Transition
Female
Homeostasis
Humans
Lung Diseases
/ metabolism
Neoplasm Metastasis
Osteoblasts
/ metabolism
Ovarian Diseases
/ metabolism
Ovarian Neoplasms
/ metabolism
Prognosis
Thyroid Diseases
/ metabolism
EMT
breast cancer
ectopic calcifications
lung
microcalcifications
osteoblast-like cells
ovary
thyroid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
03
12
2020
revised:
17
12
2020
accepted:
23
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
14
9
2021
Statut:
epublish
Résumé
The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in the formation of these calcium deposits, as well as the prognostic significance of their presence in human tissues, have not been completely elucidated. Therefore, a better characterization of the biological process related to the formation of calcifications in different tissues and organs, as well as the understanding of the prognostic significance of the presence of these calcium deposits into human tissues could significantly improve the management of patients characterized by microcalcifications associated lesions. Starting from these considerations, this narrative review highlights the most recent histopathological and molecular data concerning the formation of calcifications in breast, thyroid, lung, and ovarian diseases. Evidence reported here could deeply change the current point of view concerning the role of ectopic calcifications in the progression of human diseases and also in the patients' management. In fact, the presence of calcifications can suggest an unfavorable prognosis due to dysregulation of normal tissues homeostasis.
Identifiants
pubmed: 33374380
pii: ijms22010120
doi: 10.3390/ijms22010120
pmc: PMC7795544
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Diagn Interv Imaging. 2017 Mar;98(3):179-190
pubmed: 28131457
Br J Cancer. 2018 Oct;119(9):1129-1132
pubmed: 30327566
Rheum Dis Clin North Am. 1988 Aug;14(2):303-19
pubmed: 2845491
Atherosclerosis. 2018 Oct;277:60-65
pubmed: 30173080
Microsc Microanal. 2017 Oct;23(5):1030-1039
pubmed: 28874210
Int J Gynecol Cancer. 2018 Mar;28(3):486-492
pubmed: 29303934
Circ Res. 2013 Jun 21;113(1):72-7
pubmed: 23616621
J Transl Med. 2014 Sep 30;12:257
pubmed: 25266482
J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):25-40
pubmed: 26769216
Int J Clin Exp Med. 2013 Jun 26;6(6):413-22
pubmed: 23844264
Eur J Radiol. 2007 Feb;61(2):192-4
pubmed: 17164080
Clin Breast Cancer. 2018 Aug;18(4):e659-e669
pubmed: 29306659
Cancer Res. 2002 Sep 15;62(18):5375-80
pubmed: 12235010
Curr Atheroscler Rep. 2019 Nov 21;21(12):53
pubmed: 31754800
J Am Soc Nephrol. 2004 Jun;15(6):1392-401
pubmed: 15153550
Br J Radiol. 2009 Aug;82(980):640-4
pubmed: 19332521
J Pathol. 2005 Jan;205(2):154-71
pubmed: 15643670
Front Endocrinol (Lausanne). 2020 May 22;11:271
pubmed: 32528405
Proc Soc Exp Biol Med. 1983 Feb;172(2):173-7
pubmed: 6828462
Life Sci. 2020 Sep 15;257:118086
pubmed: 32679147
Mol Cell Endocrinol. 2019 Dec 1;498:110582
pubmed: 31525430
J Ultrasound Med. 2003 Oct;22(10):1027-31
pubmed: 14606557
Onco Targets Ther. 2019 Mar 15;12:2023-2033
pubmed: 30936719
Contrast Media Mol Imaging. 2018 Dec 9;2018:9840962
pubmed: 30627063
Sci Rep. 2019 May 1;9(1):6773
pubmed: 31043660
J Med Case Rep. 2012 Sep 04;6:279
pubmed: 22947115
Sci Rep. 2019 Oct 10;9(1):14604
pubmed: 31601987
Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):310-320
pubmed: 29684522
CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29
pubmed: 25559415
Circ Res. 2011 Jun 24;109(1):e1-12
pubmed: 21566214
J Physiol. 2016 Jun 1;594(11):2915-27
pubmed: 27040360
PLoS One. 2019 Oct 24;14(10):e0224138
pubmed: 31648281
J Cell Mol Med. 2008 Oct;12(5B):2073-82
pubmed: 18194456
Neuroradiology. 1988;30(3):265-8
pubmed: 3405417
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1753-8
pubmed: 23766262
Future Oncol. 2018 Jan;14(1):9-11
pubmed: 29219614
J Mammary Gland Biol Neoplasia. 2018 Jun;23(1-2):89-99
pubmed: 29744755
Anat Rec. 1989 Jun;224(2):234-41
pubmed: 2672888
Ann Surg Oncol. 2011 Sep;18(9):2564-8
pubmed: 21347777
Nutr Metab Cardiovasc Dis. 2017 Sep;27(9):768-774
pubmed: 28739184
Eur Radiol. 2018 Sep;28(9):3742-3750
pubmed: 29374322
Atherosclerosis. 2015 Feb;238(2):220-30
pubmed: 25528431
Adv Exp Med Biol. 2018;1097:129-155
pubmed: 30315543
Ultrasonography. 2016 Jul;35(3):212-9
pubmed: 26810196
Mod Pathol. 2003 Mar;16(3):219-22
pubmed: 12640101
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1078-1093
pubmed: 32237904
J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):181-7
pubmed: 16025224
Br J Cancer. 2012 Jan 31;106(3):525-37
pubmed: 22233923
J Biomech. 2019 Apr 18;87:1-12
pubmed: 30904335
Cells. 2020 Jun 02;9(6):
pubmed: 32498363
Future Oncol. 2018 Dec;14(30):3097-3099
pubmed: 30411977
J Clin Endocrinol Metab. 2012 Jul;97(7):E1249-56
pubmed: 22511796
Diagn Cytopathol. 2009 Jul;37(7):534-41
pubmed: 19373908
Respir Med. 2000 Mar;94(3):190-3
pubmed: 10783928
J Clin Endocrinol Metab. 2008 Jun;93(6):2409-12
pubmed: 18381576
JACC Cardiovasc Imaging. 2017 May;10(5):582-593
pubmed: 28473100
J Clin Endocrinol Metab. 2011 May;96(5):1352-9
pubmed: 21389143
Semin Cancer Biol. 2020 Feb 8;:
pubmed: 32045651
J Cancer. 2018 Feb 28;9(6):1006-1016
pubmed: 29581780
Anal Bioanal Chem. 2014 Jan;406(1):359-66
pubmed: 24202192
Br J Cancer. 2020 Nov;123(11):1644-1655
pubmed: 32934344
J Clin Endocrinol Metab. 2020 Sep 1;105(9):
pubmed: 32491169
Eur Thyroid J. 2017 Sep;6(5):225-237
pubmed: 29167761
Int J Mol Sci. 2019 Nov 11;20(22):
pubmed: 31718020
J Bone Miner Res. 2008 Nov;23(11):1798-805
pubmed: 18597635
Acta Biomater. 2006 Sep;2(5):515-20
pubmed: 16839827
BMC Cancer. 2014 Apr 23;14:286
pubmed: 24758513
J Cancer Res Ther. 2014 Nov;10 Suppl:C144-9
pubmed: 25450273
Br J Radiol. 2014 Jul;87(1039):20130496
pubmed: 24734934
Circulation. 2007 Dec 11;116(24):2782-5
pubmed: 18071088
Atherosclerosis. 2020 Aug;306:85-95
pubmed: 32654790
Radiographics. 2001 Mar-Apr;21(2):475-90
pubmed: 11259710
J Pharm Biomed Anal. 2020 Oct 25;190:113534
pubmed: 32841781
Radiographics. 2019 Mar-Apr;39(2):307-318
pubmed: 30681901
Korean J Radiol. 2016 May-Jun;17(3):370-95
pubmed: 27134526
Radiol Technol. 2013 Mar-Apr;84(4):383M-404M; quiz 405M-408M
pubmed: 23547207
Am J Respir Crit Care Med. 2002 Jun 15;165(12):1654-69
pubmed: 12070068
Cardiovasc Res. 2018 Mar 15;114(4):590-600
pubmed: 29514202
Bone. 2013 Apr;53(2):437-50
pubmed: 23334083
Microsc Res Tech. 2018 Jul;81(7):745-748
pubmed: 29633435
Calcif Tissue Int. 1983 May;35(3):327-38
pubmed: 6871763
Sci Rep. 2019 Jan 24;9(1):542
pubmed: 30679450
Dev Dyn. 2018 Mar;247(3):492-508
pubmed: 28891150
AJR Am J Roentgenol. 1987 Jan;148(1):29-30
pubmed: 3491520
Ultrasound. 2020 Aug;28(3):155-163
pubmed: 32831888
Clin Orthop Relat Res. 1995 May;(314):266-80
pubmed: 7634645
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):724-36
pubmed: 24558104
J Comput Assist Tomogr. 2018 Nov/Dec;42(6):887-897
pubmed: 30422915