Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies.
15N-direct detection
NMR
formulation condition
high ordered structure
monoclonal antibodies
multi domain
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Dec 2020
22 Dec 2020
Historique:
received:
14
11
2020
revised:
20
12
2020
accepted:
21
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Obtaining high ordered structure (HOS) information is of importance to guarantee the efficacy and safety of monoclonal antibodies (mAbs) in clinical application. Assessment of HOS should ideally be performed in a non-invasive manner under their formulated storage conditions, as any perturbation can introduce unexpected detritions. However, most of the currently available techniques only indirectly report HOS of mAbs and/or require a certain condition to conduct the analyses. Besides, the flexible multidomain architecture of mAbs has hampered atomic-resolution structural analyses using X-ray crystallography and cryo-electron microscopy. In contrast, the ability of nuclear magnetic resonance (NMR) spectroscopy to structurally analyze biomolecules in various conditions in a non-invasive and quantitative manner is suitable to meet the needs. However, the application of NMR to mAbs is not straightforward due to the high molecular weight of the system. In this review, we will discuss how NMR techniques have been applied to HOS analysis of mAbs, along with the recent advances of the novel
Identifiants
pubmed: 33375207
pii: ijms22010046
doi: 10.3390/ijms22010046
pmc: PMC7793058
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Immunoglobulin Fc Fragments
0
Immunoglobulin G
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K19415
Organisme : Japan Society for the Promotion of Science
ID : JP20H03378
Organisme : Japan Society for the Promotion of Science
ID : JP20H04722
Organisme : Takeda Science Foundation
ID : NA
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