Improvement of Executive Function after Short-Term Administration of an Antioxidants Mix Containing Bacopa, Lycopene, Astaxanthin and Vitamin B12: The BLAtwelve Study.
Aging
/ physiology
Antioxidants
/ administration & dosage
Bacopa
/ chemistry
Brain
/ drug effects
Cognition
/ drug effects
Dietary Supplements
Double-Blind Method
Executive Function
/ drug effects
Female
Humans
Lycopene
/ administration & dosage
Male
Middle Aged
Oxidative Stress
/ drug effects
Placebos
Vitamin B 12
/ administration & dosage
Xanthophylls
/ administration & dosage
antioxidants
astaxanthin
bacopa
cognitive function
lycopene
oxidative stress
vitamin B12
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 Dec 2020
27 Dec 2020
Historique:
received:
15
11
2020
revised:
20
12
2020
accepted:
22
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
2
9
2021
Statut:
epublish
Résumé
During the last few years increasing interest has been focused on antioxidants as potentially useful agents in the prevention of the onset and progression of cognitive dysfunction. In this randomized, double-blind, controlled, parallel arm study, the effects of daily consumption of an antioxidant mix on cognitive function in healthy older adults were evaluated. After a 1 week run-in period, 80 subjects aged 60 years or more, and with no evidence of cognitive dysfunction, were randomly allocated to a mix of four bioactive compounds (bacopa, lycopene, astaxanthin, and vitamin B12) or matched placebo, taken orally once a day for 8 weeks. The primary objective of the study was to evaluate the changes in trial making test (TMT) scores from baseline to 8 weeks of treatment, analyzed in the following hierarchical order: TMT-B, TMT-A, and TMT-B minus TMT-A. TMT-B increased in the control group (+3.46 s) and decreased in the active group (-17.63 s). The treatment difference was -21.01 s in favor of the active group (95% C.I. -26.80 to -15.2,
Identifiants
pubmed: 33375429
pii: nu13010056
doi: 10.3390/nu13010056
pmc: PMC7824614
pii:
doi:
Substances chimiques
Antioxidants
0
Placebos
0
Xanthophylls
0
astaxanthine
8XPW32PR7I
Vitamin B 12
P6YC3EG204
Lycopene
SB0N2N0WV6
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Menarini Industrie Farmaceutiche Riunite S.r.l., Italy
ID : MEIF/17/BAC-COG/001
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