Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI.
QSM
iron content
longitudinal study
multiple sclerosis
quantitative susceptibility mapping
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
29
05
2020
revised:
21
10
2020
accepted:
20
11
2020
pubmed:
31
12
2020
medline:
5
1
2022
entrez:
30
12
2020
Statut:
ppublish
Résumé
Increased brain iron concentration is often reported concurrently with disease development in multiple sclerosis (MS) and other neurodegenerative diseases. However, it is unclear whether the higher iron concentration in patients stems from an influx of iron into the tissue or a relative reduction in tissue compartments without much iron. By taking into account structural volume, we investigated tissue iron content in the deep gray matter (DGM) over 2 years, and compared findings to previously reported changes in iron concentration. 120 MS patients and 40 age- and sex-matched healthy controls were included. Clinical testing and MRI were performed both at baseline and after 2 years. Overall, iron content was calculated from structural MRI and quantitative susceptibility mapping in the thalamus, caudate, putamen, and globus pallidus. MS patients had significantly lower iron content than controls in the thalamus, with progressive MS patients demonstrating lower iron content than relapsing-remitting patients. Over 2 years, iron content decreased in the DGM of patients with MS, while it tended to increase or remain stable among controls. In the thalamus, decreasing iron content over 2 years was associated with disability progression. Our study showed that temporally increasing magnetic susceptibility in MS should not be considered as evidence for iron influx because it may be explained, at least partially, by disease-related atrophy. Declining DGM iron content suggests that, contrary to the current understanding, iron is being removed from the DGM in patients with MS.
Identifiants
pubmed: 33378095
doi: 10.1002/hbm.25306
pmc: PMC7927296
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1463-1474Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001412
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Radiology. 2019 Nov;293(2):424-433
pubmed: 31549947
Neuroimage. 2018 Feb 15;167:438-452
pubmed: 29097315
Nat Commun. 2016 May 10;7:11298
pubmed: 27161034
J Neuropathol Exp Neurol. 2013 Jan;72(1):42-52
pubmed: 23242281
Brain. 2005 Nov;128(Pt 11):2705-12
pubmed: 16230320
CNS Drugs. 2019 Nov;33(11):1073-1086
pubmed: 31556017
Neuroimage. 2012 Feb 1;59(3):2625-35
pubmed: 21925274
Radiology. 2010 Nov;257(2):455-62
pubmed: 20843991
J Neurol Neurosurg Psychiatry. 2012 Aug;83(8):785-92
pubmed: 22626944
Cold Spring Harb Perspect Biol. 2015 Jun 22;8(1):a020479
pubmed: 26101081
J Magn Reson Imaging. 2011 Mar;33(3):713-8
pubmed: 21563257
Eur J Neurosci. 2010 Oct;32(8):1326-36
pubmed: 20846325
Radiology. 2018 Nov;289(2):487-496
pubmed: 30015589
Physiol Rev. 2001 Apr;81(2):871-927
pubmed: 11274346
Arch Histol Cytol. 2008 Dec;71(4):205-22
pubmed: 19359804
J Magn Reson Imaging. 2018 Mar 14;:
pubmed: 29537720
J Neurochem. 1995 Aug;65(2):717-24
pubmed: 7616228
Mult Scler. 2018 Oct;24(11):1433-1444
pubmed: 28803512
Mult Scler Relat Disord. 2019 Aug;33:107-115
pubmed: 31181540
Expert Rev Neurother. 2012 Dec;12(12):1467-80
pubmed: 23237353
Expert Rev Hematol. 2017 Jan;10(1):65-79
pubmed: 27911100
J Neuropathol Exp Neurol. 2009 May;68(5):489-502
pubmed: 19525897
Hum Brain Mapp. 2021 Apr 1;42(5):1463-1474
pubmed: 33378095
Neuroimage Clin. 2017 Apr 13;18:1007-1016
pubmed: 29868452
Neuroscience. 1984 Mar;11(3):595-603
pubmed: 6717804
Radiology. 2013 Sep;268(3):831-41
pubmed: 23613615
Radiology. 2013 May;267(2):551-9
pubmed: 23315661
Mult Scler. 2016 Aug;22(9):1133-43
pubmed: 26503237
J Neurol Sci. 2009 Jul 15;282(1-2):61-6
pubmed: 19394969
Neurobiol Aging. 2014 Sep;35 Suppl 2:S51-8
pubmed: 24929968
AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2144-51
pubmed: 23721902
Lancet Neurol. 2019 Feb;18(2):198-210
pubmed: 30663609
Brain Res. 1981 Jun 29;215(1-2):317-22
pubmed: 7260591
Ann Neurol. 2013 Dec;74(6):848-61
pubmed: 23868451
AJNR Am J Neuroradiol. 2017 Jun;38(6):1079-1086
pubmed: 28450431
Nat Rev Neurosci. 2004 Nov;5(11):863-73
pubmed: 15496864
Neuroimage. 2019 Oct 1;199:545-552
pubmed: 31108214
Neuroimage. 2016 Mar;128:11-20
pubmed: 26746579
Arch Pathol Lab Med. 1982 Aug;106(8):397-9
pubmed: 6896630
Front Neurosci. 2019 Mar 01;13:180
pubmed: 30881284
J Neurochem. 2012 Jan;120(1):7-25
pubmed: 22004421
Magn Reson Imaging. 2017 Jun;39:110-122
pubmed: 28188873
Pharmaceuticals (Basel). 2018 Sep 18;11(3):
pubmed: 30231533
J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1386-95
pubmed: 24899728
PLoS One. 2014 Oct 10;9(10):e108863
pubmed: 25303286
J Magn Reson Imaging. 2000 Jun;11(6):586-95
pubmed: 10862056
Hum Brain Mapp. 2018 Oct;39(10):4007-4017
pubmed: 29923266
Neuroimage. 2019 May 1;191:337-349
pubmed: 30738207
Neuroimage. 2011 Jun 1;56(3):907-22
pubmed: 21352927
J Neurochem. 1958 Oct;3(1):41-51
pubmed: 13611557
Int J Mol Sci. 2016 Jan 14;17(1):
pubmed: 26784172
Radiology. 2012 Jan;262(1):206-15
pubmed: 22084205
J Neuroimaging. 2018 Sep;28(5):490-495
pubmed: 29856910
AJNR Am J Neuroradiol. 2019 Jan;40(1):99-106
pubmed: 30573464
Neurology. 2015 Jun 16;84(24):2396-402
pubmed: 25979698
J Magn Reson Imaging. 2019 Jul;50(1):201-208
pubmed: 30511803
Neuroimage. 2014 Dec;103:280-289
pubmed: 25264230
Neuroradiology. 2019 Jan;61(1):71-79
pubmed: 30539215
Neuroimage. 2019 Feb 1;186:308-320
pubmed: 30445148
AJNR Am J Neuroradiol. 2012 Sep;33(8):1573-8
pubmed: 22499842
Neuroimage. 2012 Sep;62(3):1593-9
pubmed: 22634862
Biochim Biophys Acta. 2015 May;1853(5):1130-44
pubmed: 25661197
Neuroimage. 2010 Oct 1;52(4):1261-7
pubmed: 20483380
Acta Neuropathol. 2017 Jul;134(1):45-64
pubmed: 28332093
Ann Neurol. 2018 Feb;83(2):210-222
pubmed: 29331092
Ann Neurol. 2002 Nov;52(5):650-3
pubmed: 12402265
Brain. 2011 Dec;134(Pt 12):3602-15
pubmed: 22171355
J Neurol Neurosurg Psychiatry. 2008 Nov;79(11):1236-44
pubmed: 18469033