ARDD 2020: from aging mechanisms to interventions.

Aging Artificial Intelligence Biomedical Research Cellular Senescence Congresses as Topic Drug Discovery Humans Life Style Longevity Pharmaceutical Preparations
aging artificial intelligence drug discovery interventions

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
30 12 2020
Historique:
received: 24 11 2020
accepted: 12 12 2020
pubmed: 31 12 2020
medline: 26 5 2021
entrez: 30 12 2020
Statut: ppublish

Résumé

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7

Identifiants

DOI: 10.18632/aging.202454 PMID: 33378272 PMC: PMC7803558
pubmed: 33378272
pii: 202454
doi: 10.18632/aging.202454
pmc: PMC7803558
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

24484-24503

Subventions

Organisme : NIA NIH HHS
ID : R56 AG056771
Pays : United States
Organisme : BLRD VA
ID : I01 BX004031
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG057792
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG050135
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056771
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG028730
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R00 AG057792
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG066311
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145560
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG047200
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG041765
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG051974
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG036695
Pays : United States
Organisme : Medical Research Council
ID : MC_UP_1605/6
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG062328
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027237
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054108
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG056278
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG065508
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063543
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017242
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG051449
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG041765
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019719
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031782
Pays : United States

Références

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):845-852
pubmed: 29304191
Nat Med. 2016 Aug;22(8):879-88
pubmed: 27400265
Subcell Biochem. 2019;91:227-247
pubmed: 30888655
J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):590-9
pubmed: 20351075
Cell Rep. 2019 Apr 9;27(2):467-480.e6
pubmed: 30970250
Front Physiol. 2019 Apr 12;10:427
pubmed: 31031645
Cell Metab. 2015 Aug 4;22(2):332-43
pubmed: 26244935
NPJ Aging Mech Dis. 2020 Jul 21;6:8
pubmed: 32714562
Cell Rep. 2016 Jul 12;16(2):520-530
pubmed: 27346343
Mol Syst Biol. 2020 Jun;16(6):e9356
pubmed: 32485097
EMBO Rep. 2020 Jun 4;21(6):e48885
pubmed: 32329196
Mol Cell. 2010 Oct 22;40(2):280-93
pubmed: 20965422
Cell Metab. 2020 Jul 7;32(1):15-30
pubmed: 32333835
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Nature. 2013 Sep 19;501(7467):416-20
pubmed: 23975097
Elife. 2019 Dec 03;8:
pubmed: 31793879
Cell. 2017 Mar 23;169(1):132-147.e16
pubmed: 28340339
Trends Pharmacol Sci. 2019 Aug;40(8):546-549
pubmed: 31279569
Aging (Albany NY). 2018 Nov 9;10(11):3249-3259
pubmed: 30414596
Nat Med. 2019 Dec;25(12):1843-1850
pubmed: 31806903
Sci Adv. 2020 Jan 31;6(5):eaax2659
pubmed: 32064334
Clin Epigenetics. 2020 Jul 13;12(1):105
pubmed: 32660606
Cell. 2020 Jul 9;182(1):12-23
pubmed: 32649873
N Engl J Med. 2017 Nov 9;377(19):1868-1876
pubmed: 29117491
Cell Rep. 2019 Sep 17;28(12):3263-3273.e3
pubmed: 31533046
Cell Metab. 2020 Jan 7;31(1):92-104.e5
pubmed: 31813824
Curr Biol. 2017 Sep 11;27(17):2652-2660.e4
pubmed: 28844647
Cell Metab. 2016 Jun 14;23(6):1078-1092
pubmed: 27304508
Nat Metab. 2019 Oct;1(10):931-932
pubmed: 32694837
Nat Commun. 2020 Feb 25;11(1):1043
pubmed: 32098962
Nat Commun. 2020 Jan 31;11(1):645
pubmed: 32005807
Nature. 2013 May 23;497(7450):451-7
pubmed: 23698443
Nat Commun. 2020 Sep 15;11(1):4618
pubmed: 32934233
Biogerontology. 2020 Dec;21(6):817-826
pubmed: 32793997
Physiol Rep. 2019 Jul;7(12):e14139
pubmed: 31207144
Exp Biol Med (Maywood). 2017 Jul;242(13):1325-1334
pubmed: 28581336
Nat Neurosci. 2019 Mar;22(3):401-412
pubmed: 30742114
Mol Cell Proteomics. 2012 Oct;11(10):989-1007
pubmed: 22801418
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32259199
Cell Rep. 2017 Mar 28;18(13):3052-3062
pubmed: 28355558
Cell. 2019 Apr 18;177(3):622-638.e22
pubmed: 31002797
Sci Adv. 2016 Jul 29;2(7):e1600584
pubmed: 27482540
Aging Cell. 2020 Oct;19(10):e13230
pubmed: 33006233
Circulation. 2018 Mar 27;137(13):1364-1373
pubmed: 29162611
Elife. 2020 Apr 07;9:
pubmed: 32254024
Cell Metab. 2020 Mar 3;31(3):549-563.e7
pubmed: 32084377
Sci Rep. 2019 Jun 24;9(1):9151
pubmed: 31235842
PLoS Biol. 2018 Jun 11;16(6):e2004663
pubmed: 29889904
Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381
pubmed: 29626215
Nucleic Acids Res. 2019 Aug 22;47(14):7294-7305
pubmed: 31251810
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9014-9019
pubmed: 30992375
Aging Cell. 2019 Dec;18(6):e13028
pubmed: 31496122
Aging Cell. 2018 Aug;17(4):e12740
pubmed: 29671950
Mech Ageing Dev. 2020 Mar;186:111212
pubmed: 32017944
Cell Metab. 2016 Jun 14;23(6):1013-1021
pubmed: 27304503
Ageing Res Rev. 2020 Sep;62:101094
pubmed: 32512174
Nat Metab. 2019 Jun;1(6):595-603
pubmed: 32694802
Dev Cell. 2019 Jul 22;50(2):167-183.e8
pubmed: 31336098
Mech Ageing Dev. 2019 Jan;177:186-200
pubmed: 30044947
Gerontology. 2020;66(3):231-237
pubmed: 31914446
Nat Commun. 2019 Feb 8;10(1):666
pubmed: 30737381
EBioMedicine. 2018 Oct;36:18-28
pubmed: 30279143
Cell. 2015 Dec 3;163(6):1539-54
pubmed: 26638078
Annu Rev Genet. 2019 Dec 3;53:239-261
pubmed: 31487470
Cell Metab. 2020 Sep 1;32(3):447-456.e6
pubmed: 32877690
Trends Mol Med. 2020 Jan;26(1):8-20
pubmed: 31375365
Sci Rep. 2017 Oct 2;7(1):12480
pubmed: 28970491
Mech Ageing Dev. 2020 Oct;191:111328
pubmed: 32800796
Cell Metab. 2019 Sep 3;30(3):573-593.e8
pubmed: 31353263
Elife. 2020 Jan 29;9:
pubmed: 31995034
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
Nat Commun. 2018 Jun 4;9(1):2167
pubmed: 29867199
Nat Metab. 2020 Apr;2(4):307-317
pubmed: 32601609
Trends Genet. 2017 May;33(5):303-321
pubmed: 28365140
Trends Cell Biol. 2020 Feb;30(2):117-132
pubmed: 31917080
Science. 2019 Sep 27;365(6460):1466-1469
pubmed: 31604276
Nat Rev Genet. 2016 Oct;17(10):615-29
pubmed: 27498692
Proteomics. 2020 Mar;20(5-6):e1900408
pubmed: 32084299
Nature. 2017 Apr 13;544(7649):185-190
pubmed: 28379943
Cell Metab. 2019 Oct 1;30(4):630-655
pubmed: 31577933
Ageing Res Rev. 2020 Dec;64:101188
pubmed: 33031925
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3053-3062
pubmed: 31980526
Autophagy. 2019 Jun;15(6):1112-1114
pubmed: 30922179
Science. 2015 Dec 4;350(6265):1208-13
pubmed: 26785480
Cell. 2019 Sep 5;178(6):1299-1312.e29
pubmed: 31474368
Aging Cell. 2016 Apr;15(2):256-66
pubmed: 26676933
iScience. 2020 Jun 26;23(6):101199
pubmed: 32534441
Aging Cell. 2017 Aug;16(4):895-897
pubmed: 28600811
Trends Biotechnol. 2017 Nov;35(11):1062-1073
pubmed: 28778607
Lancet Neurol. 2018 Sep;17(9):802-815
pubmed: 30129476
Nat Rev Endocrinol. 2020 Mar;16(3):133-134
pubmed: 31992872
Elife. 2020 Dec 15;9:
pubmed: 33319750
Nat Struct Mol Biol. 2020 Dec;27(12):1165-1177
pubmed: 33046905
JAMA Netw Open. 2020 Jul 1;3(7):e209250
pubmed: 32648923
Elife. 2017 Aug 22;6:
pubmed: 28826469
Interdiscip Top Gerontol. 2014;39:45-61
pubmed: 24862014
J Pathol. 2020 May;251(1):100-112
pubmed: 32154592
Mol Cell Biol. 2019 Sep 11;39(19):
pubmed: 31308131
Aging (Albany NY). 2019 Nov 25;11(22):10771-10780
pubmed: 31767810
Cell Death Dis. 2019 Feb 12;10(2):126
pubmed: 30755597
BMC Cell Biol. 2017 Oct 17;18(1):31
pubmed: 29041897
Mol Metab. 2016 Jul 16;5(10):1042-1047
pubmed: 27689017
Cell Signal. 2010 Apr;22(4):573-7
pubmed: 19861158
Cell Metab. 2020 Aug 4;32(2):203-214.e4
pubmed: 32413333
Genome Biol. 2020 Apr 7;21(1):91
pubmed: 32264951
Nat Biotechnol. 2019 Sep;37(9):1038-1040
pubmed: 31477924
Lancet Digit Health. 2019 Jun;1(2):e78-e89
pubmed: 33323232

Auteurs

Garik V Mkrtchyan (GV)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Kotb Abdelmohsen (K)

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

Pénélope Andreux (P)

Amazentis SA, EPFL Innovation Park, Bâtiment C, Lausanne, Switzerland.

Ieva Bagdonaite (I)

Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Nir Barzilai (N)

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Søren Brunak (S)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Filipe Cabreiro (F)

Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.

Rafael de Cabo (R)

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Judith Campisi (J)

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Ana Maria Cuervo (AM)

Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Marco Demaria (M)

European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, The Netherlands.

Collin Y Ewald (CY)

Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology Zürich, Switzerland.

Evandro Fei Fang (EF)

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.

Richard Faragher (R)

School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.

Luigi Ferrucci (L)

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Adam Freund (A)

Calico Life Sciences, LLC, South San Francisco, CA 94080, USA.

Carlos G Silva-García (CG)

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Anastasia Georgievskaya (A)

HautAI OÜ, Tallinn, Estonia.

Vadim N Gladyshev (VN)

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

David J Glass (DJ)

Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591, USA.

Vera Gorbunova (V)

Departments of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.

Aubrey de Grey (A)

SENS Research Foundation, Mountain View, CA 94041, USA.

Wei-Wu He (WW)

Human Longevity Inc., San Diego, CA 92121, USA.

Jan Hoeijmakers (J)

Department of Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Eva Hoffmann (E)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Steve Horvath (S)

Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Riekelt H Houtkooper (RH)

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Majken K Jensen (MK)

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Martin Borch Jensen (MB)

Gordian Biotechnology, San Francisco, CA 94107, USA.

Alice Kane (A)

Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA.

Moustapha Kassem (M)

Molecular Endocrinology Unit, Department of Endocrinology, University Hospital of Odense and University of Southern Denmark, Odense, Denmark.

Peter de Keizer (P)

Department of Molecular Cancer Research, Center for Molecular Medicine, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Brian Kennedy (B)

Buck Institute for Research on Aging, Novato, CA 94945, USA.
Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.
Centre for Healthy Ageing, National University Healthy System, Singapore.

Gerard Karsenty (G)

Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.

Dudley W Lamming (DW)

Department of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792, USA.

Kai-Fu Lee (KF)

Sinovation Ventures and Sinovation AI Institute, Beijing, China.

Nanna MacAulay (N)

Department of Neuroscience, University of Copenhagen, Denmark.

Polina Mamoshina (P)

Deep Longevity Inc., Hong Kong Science and Technology Park, Hong Kong.

Jim Mellon (J)

Juvenescence Limited, Douglas, Isle of Man, UK.

Marte Molenaars (M)

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Alexey Moskalev (A)

Institute of Biology of FRC Komi Science Center of Ural Division of RAS, Syktyvkar, Russia.

Andreas Mund (A)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Laura Niedernhofer (L)

Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Brenna Osborne (B)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Heidi H Pak (HH)

Department of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792, USA.

Andrey Parkhitko (A)

University of Pittsburgh, Pittsburgh, PA 15260, USA.

Nuno Raimundo (N)

Institute of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.

Thomas A Rando (TA)

Department of Neurology and Neurological Sciences and Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.

Lene Juel Rasmussen (LJ)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Carolina Reis (C)

OneSkin Inc., San Francisco, CA 94107, USA.

Christian G Riedel (CG)

Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.

Anais Franco-Romero (A)

Department of Biomedical Sciences, University of Padova, Italy.

Björn Schumacher (B)

Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Cologne, Germany.

David A Sinclair (DA)

Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA.
Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia.

Yousin Suh (Y)

Departments of Obstetrics and Gynecology, Genetics and Development, Columbia University, New York, NY 10027, USA.

Pam R Taub (PR)

Division of Cardiovascular Medicine, University of California, San Diego, CA 92093, USA.

Debra Toiber (D)

Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Jonas T Treebak (JT)

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Dario Riccardo Valenzano (DR)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Eric Verdin (E)

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Jan Vijg (J)

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Sergey Young (S)

Longevity Vision Fund, New York, NY 10022, USA.

Lei Zhang (L)

Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Daniela Bakula (D)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Alex Zhavoronkov (A)

Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong.

Morten Scheibye-Knudsen (M)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Congrès comme sujet › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Phénomènes physiologiques › Longévité › ARDD 2020: from aging mechanisms to interventions.
questionsmedicales.fr › Préparations pharmaceutiques › ARDD 2020: from aging mechanisms to interventions.