Formulation development and characterization of lumefantrine nanosuspension for enhanced antimalarial activity.

Antimalarials Lumefantrine Nanoparticles Particle Size Solubility Suspensions
Lumefantrine Nanosuspension Oral bioavailability anti-malarial agent drug delivery solubility

Journal

Journal of biomaterials science. Polymer edition
ISSN: 1568-5624
Titre abrégé: J Biomater Sci Polym Ed
Pays: England
ID NLM: 9007393

Informations de publication

Date de publication:
05 2021
Historique:
pubmed: 1 1 2021
medline: 16 10 2021
entrez: 31 12 2020
Statut: ppublish

Résumé

Variable and low oral bioavailability (4-11%) of lumefantrine (LUF), an anti-malarial agent, is characterized by very low solubility in aqueous vehicle. Thus, the present study was intended to formulate lyophilized nanosuspensions of LUF to resolve its solubility issues for the improvement of oral bioavailability. A three level 3

Identifiants

DOI: 10.1080/09205063.2020.1870378 PMID: 33380264
pubmed: 33380264
doi: 10.1080/09205063.2020.1870378
doi:

Substances chimiques

Antimalarials 0
Suspensions 0
Lumefantrine F38R0JR742

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

833-857

Auteurs

Ripalkumar Shah (R)

Faculty of Pharmacy, Dharamsinh Desai University, Nadiad, Gujarat, India.
Caplin Point Laboratories Limited (R&D), Chennai, Tamilnadu, India.

Tejal Soni (T)

Faculty of Pharmacy, Dharamsinh Desai University, Nadiad, Gujarat, India.

Unnati Shah (U)

Caplin Point Laboratories Limited (R&D), Chennai, Tamilnadu, India.

B N Suhagia (BN)

Faculty of Pharmacy, Dharamsinh Desai University, Nadiad, Gujarat, India.

M N Patel (MN)

Faculty of Pharmacy, Dharamsinh Desai University, Nadiad, Gujarat, India.

Tejas Patel (T)

Faculty of Pharmacy, Dharamsinh Desai University, Nadiad, Gujarat, India.

Gamal A Gabr (GA)

Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Agricultural Genetic Engineering Research Institute, Agriculture Research Center, Giza, Egypt.

Bapi Gorain (B)

School of Pharmacy, Faculty of Health and Medical Science, Taylor's University, Subang Jaya, Selengor, Malaysia.
Centre for Drug Delivery and Molecular Pharmacology, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia.

Prashant Kesharwani (P)

Department of Pharmaceutics, School of Pharmaceutical Education and Research, New Delhi, Delhi, India.
ORCID: 0000-0002-0890-769X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Formulation development and characterization...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Fluorènes › Luméfantrine › Formulation development and characterization...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Formulation development and characterization...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Formulation development and characterization...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Formulation development and characterization...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Suspensions › Formulation development and characterization...