Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.


Journal

The Yale journal of biology and medicine
ISSN: 1551-4056
Titre abrégé: Yale J Biol Med
Pays: United States
ID NLM: 0417414

Informations de publication

Date de publication:
12 2020
Historique:
entrez: 31 12 2020
pubmed: 1 1 2021
medline: 26 11 2021
Statut: epublish

Résumé

Allergic contact dermatitis (ACD) is a complex immunological allergic disease characterized by the interplay between the innate and adaptive immune system. Initially, the role of the innate immune system was believed to be confined to the initial sensitization phase, while adaptive immune reactions were linked with the advanced elicitation phase. However, recent data predicted a comparatively mixed and interdependent role of both immune systems throughout the disease progression. Therefore, the actual mechanisms of disease progression are more complex and interlinked. The aim of this review is to combine such findings that enhanced our understanding of the pathomechanisms of ACD. Here, we focused on the main cell types from both immune domains, which are involved in ACD, such as CD4

Identifiants

pubmed: 33380932
pii: yjbm935699
pmc: PMC7757059

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

699-709

Informations de copyright

Copyright ©2020, Yale Journal of Biology and Medicine.

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Auteurs

Muhammad Azeem (M)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Hidaya Kader (H)

Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.

Andreas Kerstan (A)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Helal F Hetta (HF)

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Edgar Serfling (E)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Matthias Goebeler (M)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Khalid Muhammad (K)

Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.

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