MCAM/CD146 Signaling
integrin
PLCγ1 activation
T-cell
adhesion
melanoma cell adhesion molecule/CD146
multiple sclerosis
neuroinflammation
recruitment
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
09
2020
accepted:
13
11
2020
entrez:
31
12
2020
pubmed:
1
1
2021
medline:
17
6
2021
Statut:
epublish
Résumé
Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune cells have to overcome the endothelium and transmigrate into the tissue. Numerous molecules mediate this process and, as they determine the tissue invasiveness of immune cells, display great therapeutic potential. Melanoma cell adhesion molecule (MCAM) is a membrane-anchored glycoprotein expressed by a subset of T-cells and MCAM+ T-cells have been shown to contribute to neuroinflammation in multiple sclerosis. The role of the MCAM molecule for brain invasion, however, remained largely unknown. In order to investigate the role of the MCAM molecule on T-cells, we used different
Identifiants
pubmed: 33381120
doi: 10.3389/fimmu.2020.599936
pmc: PMC7767877
doi:
Substances chimiques
CD146 Antigen
0
Integrin beta1
0
Itgb1 protein, mouse
0
Mcam protein, mouse
0
Phospholipase C gamma
EC 3.1.4.3
Plcg1 protein, mouse
EC 3.1.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
599936Informations de copyright
Copyright © 2020 Zondler, Herich, Kotte, Körner, Schneider-Hohendorf, Wiendl, Schwab and Zarbock.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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