The negative role of histone acetylation in cobalt chloride-induced neurodegenerative damages in SHSY5Y cells.

Acetylation / drug effects Amyloid Precursor Protein Secretases / genetics Aspartic Acid Endopeptidases / genetics Cell Line, Tumor Cobalt / metabolism Epigenesis, Genetic / drug effects Histone Deacetylase Inhibitors / metabolism Histones / metabolism Humans Hydroxamic Acids Nervous System / drug effects Neuroblastoma / genetics Toxicity Tests
Cobalt chloride Epigenetic regulation Histone acetyltransferase/deacetylase Histone modification Neurotoxicity

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 03 10 2020
revised: 13 12 2020
accepted: 18 12 2020
pubmed: 1 1 2021
medline: 30 1 2021
entrez: 31 12 2020
Statut: ppublish

Résumé

Cobalt has been known for its neurotoxicity in numerous studies. However, the molecular mechanism underlying cobalt-induced neurotoxicity remains largely unknown. In this study, two neuroblastoma (SHSY5Y and N2a) cell lines and a phaeochromocytoma (PC12) line were used as in vitro models. Cells were treated for 24 h with 50, 100, 200, 300, 400 µM cobalt chloride (CoCl

Identifiants

DOI: 10.1016/j.ecoenv.2020.111832 PMID: 33383341
pubmed: 33383341
pii: S0147-6513(20)31668-7
doi: 10.1016/j.ecoenv.2020.111832
pii:
doi:

Substances chimiques

Histone Deacetylase Inhibitors 0
Histones 0
Hydroxamic Acids 0
Cobalt 3G0H8C9362
trichostatin A 3X2S926L3Z
Amyloid Precursor Protein Secretases EC 3.4.-
Aspartic Acid Endopeptidases EC 3.4.23.-
cobaltous chloride EVS87XF13W

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111832

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Zhenkun Guo (Z)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Jianping Tang (J)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Junxiang Wang (J)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Fuli Zheng (F)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Chunchun Zhang (C)

Department of Clinical Laboratory, Longyan People Hospital, Longyan 364000, China.

Yuan-Liang Wang (YL)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Ping Cai (P)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Wenya Shao (W)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Guangxia Yu (G)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China.

Siying Wu (S)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China. Electronic address: sywu@fjmu.edu.cn.

Huangyuan Li (H)

Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou 350122, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou 350122, China. Electronic address: lhy@fjmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Acylation › Acétylation › The negative role of histone acetylation in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Amyloid precursor protein secretases › The negative role of histone acetylation in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › The negative role of histone acetylation in...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › The negative role of histone acetylation in...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cobalt › The negative role of histone acetylation in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The negative role of histone acetylation in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › The negative role of histone acetylation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › The negative role of histone acetylation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The negative role of histone acetylation in...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Acides hydroxamiques › The negative role of histone acetylation in...
questionsmedicales.fr › Système nerveux › The negative role of histone acetylation in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › The negative role of histone acetylation in...
questionsmedicales.fr › Techniques d'investigation › Tests de toxicité › The negative role of histone acetylation in...