CSF plasmablasts differentiate MS from other neurologic disorders.
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
14
11
2020
revised:
16
12
2020
accepted:
21
12
2020
pubmed:
1
1
2021
medline:
15
5
2021
entrez:
31
12
2020
Statut:
ppublish
Résumé
Multiparametric flow cytometry (FC) of CSF allows one to easily estimate the percentage of lymphocyte subpopulations in CSF. We hypothesized that an increased ratio of B-lineage cells in CSF of MS patients, as assessed with FC, could be useful for diagnostics. We analyzed CSF of 137 patients (70 MS, 24 infectious/autoimmune neurologic disorders (INDs), and 43 non-infectious/autoimmune neurologic disorders (NINDs)), and showed that CSF plasmablasts of >0.1% had a sensitivity of 40% for MS and specificity of 92% when comparing MS and IND, while plasmablasts of >0.25% had sensitivity of 36%, and 100% specificity.
Identifiants
pubmed: 33383365
pii: S2211-0348(20)30793-8
doi: 10.1016/j.msard.2020.102719
pii:
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
102719Informations de copyright
Copyright © 2020. Published by Elsevier B.V.