Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment.
SNPs
genetic association analysis
impaired spermatogenesis
infertility
non-obstructive azoospermia
severe oligospermia
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
29 Dec 2020
29 Dec 2020
Historique:
received:
14
11
2020
revised:
05
12
2020
accepted:
25
12
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
2
1
2021
Statut:
epublish
Résumé
Infertility is a growing concern in developed societies. Two extreme phenotypes of male infertility are non-obstructive azoospermia (NOA) and severe oligospermia (SO), which are characterized by severe spermatogenic failure (SpF). We designed a genetic association study comprising 725 Iberian infertile men as a consequence of SpF and 1058 unaffected controls to evaluate whether five single-nucleotide polymorphisms (SNPs), previously associated with reduced fertility in Hutterites, are also involved in the genetic susceptibility to idiopathic SpF and specific clinical entities. A significant difference in the allele frequencies of
Identifiants
pubmed: 33383876
pii: jpm11010022
doi: 10.3390/jpm11010022
pmc: PMC7823507
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2016-78722-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : RYC-2014-16458
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : IJC2018-038026-I
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