Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System.
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
/ immunology
Cytokine Release Syndrome
/ immunology
Cytokines
/ blood
Dysbiosis
/ pathology
Gastrointestinal Microbiome
/ physiology
HIV Infections
/ immunology
Humans
Lymphopenia
/ pathology
SARS-CoV-2
/ immunology
Tight Junctions
/ pathology
CD4 exhaustion
COVID-19
HIV
cytokine storm
leaky gut
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
08
2020
accepted:
17
11
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
16
1
2021
Statut:
epublish
Résumé
COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outcome. As CD4+ T cells play a critical role in orchestrating responses against viral infections, important lessons can be drawn by comparing T cell response in COVID-19 and in HIV infection and by studying HIV-infected patients who became infected by SARS-CoV-2. We critically reviewed host characteristics and hyper-inflammatory response in these two viral infections to have a better insight on the large difference in clinical outcome in persons being infected by SARS-CoV-2. The better understanding of mechanism of T cell dysfunction will contribute to the development of targeted therapy against severe COVID-19 and will help to rationally design vaccine involving T cell response for the long-term control of viral infection.
Identifiants
pubmed: 33384690
doi: 10.3389/fimmu.2020.596631
pmc: PMC7770166
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
596631Informations de copyright
Copyright © 2020 Peng, Ouyang, Isnard, Lin, Fombuena, Zhu and Routy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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