Vitamin D for Growth and Rickets in Stunted Children: A Randomized Trial.
Afghanistan
/ epidemiology
Bone Density Conservation Agents
/ therapeutic use
Calcium, Dietary
/ administration & dosage
Cholecalciferol
/ therapeutic use
Double-Blind Method
Female
Growth Disorders
/ drug therapy
Humans
Infant
Infant, Newborn
Male
Parathyroid Hormone
/ blood
Prevalence
Rickets
/ epidemiology
Urban Population
Vitamin D
/ analogs & derivatives
Journal
Pediatrics
ISSN: 1098-4275
Titre abrégé: Pediatrics
Pays: United States
ID NLM: 0376422
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
accepted:
20
10
2020
entrez:
2
1
2021
pubmed:
3
1
2021
medline:
11
5
2021
Statut:
ppublish
Résumé
Vitamin D is essential for healthy development of bones, but little is known about the effects of supplementation in young stunted children. Our objective was to assess the effect of vitamin D supplementation on risk of rickets and linear growth among Afghan children. In this double-blind, placebo-controlled trial, 3046 children ages 1 to 11 months from inner-city Kabul were randomly assigned to receive oral vitamin D Mean (95% confidence interval [CI]) serum 25-hydroxyvitamin D (seasonally corrected) and dietary calcium intake were insufficient at 37 (35-39) nmol/L and 372 (327-418) mg/day, respectively. Prevalence of rickets was 5.5% (placebo) and 5.3% (vitamin D): odds ratio 0.96 (95% CI: 0.48 to 1.92); Except in those with higher calcium intake, vitamin D supplementation had no effect on rickets or growth.
Sections du résumé
BACKGROUND AND OBJECTIVES
Vitamin D is essential for healthy development of bones, but little is known about the effects of supplementation in young stunted children. Our objective was to assess the effect of vitamin D supplementation on risk of rickets and linear growth among Afghan children.
METHODS
In this double-blind, placebo-controlled trial, 3046 children ages 1 to 11 months from inner-city Kabul were randomly assigned to receive oral vitamin D
RESULTS
Mean (95% confidence interval [CI]) serum 25-hydroxyvitamin D (seasonally corrected) and dietary calcium intake were insufficient at 37 (35-39) nmol/L and 372 (327-418) mg/day, respectively. Prevalence of rickets was 5.5% (placebo) and 5.3% (vitamin D): odds ratio 0.96 (95% CI: 0.48 to 1.92);
CONCLUSIONS
Except in those with higher calcium intake, vitamin D supplementation had no effect on rickets or growth.
Identifiants
pubmed: 33386335
pii: peds.2020-0815
doi: 10.1542/peds.2020-0815
pii:
doi:
Substances chimiques
Bone Density Conservation Agents
0
Calcium, Dietary
0
Parathyroid Hormone
0
Vitamin D
1406-16-2
Cholecalciferol
1C6V77QF41
25-hydroxyvitamin D
A288AR3C9H
Banques de données
ClinicalTrials.gov
['NCT00548379']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 082476/Z/07/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 by the American Academy of Pediatrics.
Déclaration de conflit d'intérêts
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.