Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort.
Covid-19
Diabetes
Mortality
Propensity score-matching
Journal
Diabetes & metabolism
ISSN: 1878-1780
Titre abrégé: Diabetes Metab
Pays: France
ID NLM: 9607599
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
09
09
2020
revised:
07
12
2020
accepted:
08
12
2020
pubmed:
4
1
2021
medline:
20
8
2021
entrez:
3
1
2021
Statut:
ppublish
Résumé
Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients' characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death. After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM. NCT04344327.
Sections du résumé
BACKGROUND
Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19.
METHODS
This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients' characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death.
RESULTS
After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m
CONCLUSION
In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM.
TRIAL REGISTRATION NUMBER
NCT04344327.
Identifiants
pubmed: 33388386
pii: S1262-3636(20)30279-2
doi: 10.1016/j.diabet.2020.101222
pmc: PMC7774010
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT04344327']
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
101222Informations de copyright
Copyright © 2020. Published by Elsevier Masson SAS.
Références
Eur Heart J. 2020 Jun 7;41(22):2058-2066
pubmed: 32498076
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Cell Metab. 2020 Jun 2;31(6):1068-1077.e3
pubmed: 32369736
BMJ. 2007 Oct 20;335(7624):806-8
pubmed: 17947786
Diabetes Metab. 2020 Sep;46(4):335-337
pubmed: 32416321
Lancet Diabetes Endocrinol. 2020 Jul;8(7):562-564
pubmed: 32437642
Diabetes Metab. 2020 Sep;46(4):265-271
pubmed: 32447101
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Diabetologia. 2020 Oct;63(10):2102-2111
pubmed: 32647915
Diabetes Care. 2020 Jul;43(7):1382-1391
pubmed: 32409504
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Eur Heart J. 2020 Jul 1;41(32):3058-3068
pubmed: 32656565
Curr Med Res Opin. 2016 Jul;32(7):1243-52
pubmed: 26986190
BMJ Open Diabetes Res Care. 2020 Apr;8(1):
pubmed: 32345579
JAMA Cardiol. 2020 Jul 1;5(7):802-810
pubmed: 32211816
BMJ. 2020 May 22;369:m1966
pubmed: 32444366
Multivariate Behav Res. 2011 May;46(3):399-424
pubmed: 21818162
JAMA. 2020 May 12;323(18):1775-1776
pubmed: 32203977
Lancet Diabetes Endocrinol. 2020 Oct;8(10):813-822
pubmed: 32798472
Int Urol Nephrol. 2020 Jul;52(7):1405-1406
pubmed: 32458212
Diabetologia. 2020 Aug;63(8):1500-1515
pubmed: 32472191
Lancet. 2020 Jun 6;395(10239):1763-1770
pubmed: 32442528
BMJ. 2020 May 29;369:m1996
pubmed: 32471884
Diabetes Metab. 2021 Mar;47(2):101178
pubmed: 32738402
BMJ. 2020 May 22;369:m1985
pubmed: 32444460