Opioid effect on the autonomic nervous system in a fetal sheep model.
Autonomic nervous system
Fetal heart rate
Fetal sheep
Nalbuphine
Opioid
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
05
05
2020
accepted:
21
11
2020
pubmed:
4
1
2021
medline:
29
10
2021
entrez:
3
1
2021
Statut:
ppublish
Résumé
Opioid use during labour can interfere with cardiotocography patterns. Heart rate variability indirectly reflects a fluctuation in the autonomic nervous system and can be monitored through time and spectral analyses. This experimental study aimed to evaluate the impact of nalbuphine administration on the gasometric, cardiovascular, and autonomic nervous system responses in fetal sheep. This was an experimental study on chronically instrumented sheep fetuses (surgery at 128 ± 2 days of gestational age, term = 145 days). The model was based on a maternal intravenous bolus injection of nalbuphine, a semisynthetic opioid used as an analgesic during delivery. Fetal gasometric parameters (pH, pO Eleven experiments were performed. Fetal heart rate, mean arterial pressure, and activities at low and high frequencies were stable after injection. Short-term variation decreased at T30 min (P = 0.02), and long-term variation decreased at T60 min (P = 0.02). Fetal stress index gradually increased and reached significance at T60 min (P = 0.02). Fetal gasometric parameters and lactate levels remained stable. Maternal nalbuphine use during labour may lead to fetal heart changes that are caused by the effect of opioid on the autonomic nervous system; these fluctuations do not reflect acidosis.
Identifiants
pubmed: 33389095
doi: 10.1007/s00404-020-05917-4
pii: 10.1007/s00404-020-05917-4
doi:
Substances chimiques
Analgesics, Opioid
0
Nalbuphine
L2T84IQI2K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-80Références
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