Fluconazole for Hypercortisolism in Cushing's Disease: A Case Report and Literature Review.
Antifungal Agents
/ therapeutic use
Brain
/ diagnostic imaging
Cryptococcosis
/ diagnostic imaging
Cryptococcus neoformans
Cushing Syndrome
/ diagnostic imaging
Female
Fluconazole
/ therapeutic use
Humans
Lung
/ diagnostic imaging
Lung Diseases, Fungal
/ drug therapy
Magnetic Resonance Imaging
Middle Aged
Neurosurgical Procedures
Pituitary ACTH Hypersecretion
/ diagnostic imaging
Tomography, X-Ray Computed
Treatment Outcome
Cushing’s disease
Cushing’s syndrome
fluconazole
hypercortisolism
medical treatment
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
09
2020
accepted:
12
11
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Cushing's disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery. We report a case of a patient with Cushing's disease and pulmonary Cushing's disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing's disease patients with cryptococcal pneumonia.
Sections du résumé
Background
Cushing's disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery.
Case
We report a case of a patient with Cushing's disease and pulmonary
Conclusion
Cushing's disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing's disease patients with cryptococcal pneumonia.
Identifiants
pubmed: 33391186
doi: 10.3389/fendo.2020.608886
pmc: PMC7774647
doi:
Substances chimiques
Antifungal Agents
0
Fluconazole
8VZV102JFY
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
608886Informations de copyright
Copyright © 2020 Zhao, Liang, Cai, Wu and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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