Clinical and Genetic Spectrum of a Large Cohort of Patients With Leukocyte Adhesion Deficiency Type 1 and 3: A Multicentric Study From India.
Adolescent
CD18 Antigens
/ genetics
Cell Adhesion
/ genetics
Child
Child, Preschool
Cohort Studies
Female
Humans
India
Infant
Infant, Newborn
Leukocyte-Adhesion Deficiency Syndrome
/ genetics
Leukocytes
/ pathology
Leukocytosis
/ genetics
Male
Membrane Proteins
/ genetics
Mutation
/ genetics
Neutrophils
/ pathology
CD11
CD18
FERMT3
ITGβ2
Leukocyte Adhesion deficiency
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
09
2020
accepted:
09
11
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Leukocyte adhesion deficiency (LAD) syndrome is a group of inborn errors of immunity characterized by a defect in the cascade of the activation and adhesion leading to the failure of leukocyte to migrate to the site of tissue injury. Three different types of LAD have been described. The most common subtype is LAD type 1 (LAD1) caused due to defects in the
Identifiants
pubmed: 33391282
doi: 10.3389/fimmu.2020.612703
pmc: PMC7772426
doi:
Substances chimiques
CD18 Antigens
0
Membrane Proteins
0
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
612703Informations de copyright
Copyright © 2020 Kambli, Bargir, Yadav, Gupta, Dalvi, Hule, Kelkar, Sawant-Desai, Setia, Jodhawat, Nambiar, Dhawale, Gaikwad, Shinde, Taur, Gowri, Pandrowala, Gupta, Joshi, Sharma, Arora, Pilania, Chaudhary, Agarwal, Katiyar, Bhattad, Ramprakash, CP, Jayaram, Gornale, Raj, Uppuluri, Sivasankaran, Munirathnam, Lashkari, Kalra, Sachdeva, Sharma, Balaji, Govindraj, Karande, Nanavati, Manglani, Subramanyam, Sampagar, CK, Gutha, Kanakia, Mundada, Krishna, Nampoothiri, Nemani, Rawat, Desai and Madkaikar.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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