Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation.
Animals
Genes, Reporter
Hippocampus
/ metabolism
Inflammation
/ metabolism
Interferon-gamma
/ metabolism
Interleukin-10
/ metabolism
Interleukin-1beta
/ metabolism
Interleukin-6
/ metabolism
Lipopolysaccharides
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microglia
/ metabolism
Neuronal Plasticity
/ drug effects
Neurons
/ metabolism
Organoids
Synaptic Transmission
/ physiology
Transcranial Magnetic Stimulation
Tumor Necrosis Factor-alpha
/ metabolism
TNFα-reporter mouse
interleukin 10
neuroinflammation
non-invasive brain stimulation
synaptic plasticity
transcranial magnetic stimulation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
10
2020
accepted:
16
11
2020
entrez:
4
1
2021
pubmed:
5
1
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Systemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by LPS-induced inflammation. Specifically, we explored brain tissue cultures to learn more about the direct effects of LPS on neural tissue, and we tested for the plasticity-restoring effects of the anti-inflammatory cytokine interleukin 10 (IL10). As shown previously, 10 Hz repetitive magnetic stimulation (rMS) of organotypic entorhino-hippocampal tissue cultures induced a robust increase in excitatory neurotransmission onto CA1 pyramidal neurons. Furthermore, LPS-treated tissue cultures did not express rMS-induced synaptic plasticity. Live-cell microscopy in tissue cultures prepared from a novel transgenic reporter mouse line [
Identifiants
pubmed: 33391287
doi: 10.3389/fimmu.2020.614509
pmc: PMC7772211
doi:
Substances chimiques
IL10 protein, mouse
0
Interleukin-1beta
0
Interleukin-6
0
Lipopolysaccharides
0
Tumor Necrosis Factor-alpha
0
interleukin-6, mouse
0
Interleukin-10
130068-27-8
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
614509Subventions
Organisme : NINDS NIH HHS
ID : R01 NS109498
Pays : United States
Informations de copyright
Copyright © 2020 Lenz, Eichler, Kruse, Strehl, Rodriguez-Rozada, Goren, Yogev, Frank, Waisman, Deller, Jung, Maggio and Vlachos.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Commun. 2016 Jan 08;7:10020
pubmed: 26743822
J Exp Med. 2014 Jul 28;211(8):1533-49
pubmed: 25002752
J Mol Med (Berl). 2018 Oct;96(10):1039-1047
pubmed: 30073573
Nucleic Acids Res. 1999 Mar 15;27(6):1555-7
pubmed: 10037821
Exp Neurol. 2017 Sep;295:233-242
pubmed: 28624361
Nat Rev Neurosci. 2001 Oct;2(10):734-44
pubmed: 11584311
Clin Neurophysiol. 2004 Aug;115(8):1717-29
pubmed: 15261850
J Neurosci. 1999 Apr 15;19(8):3198-203
pubmed: 10191332
Nat Methods. 2014 Sep;11(9):879-80
pubmed: 25317452
Brain Struct Funct. 2015 Nov;220(6):3323-37
pubmed: 25108309
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
Neuron. 2015 Feb 4;85(3):534-48
pubmed: 25619654
J Neuroinflammation. 2015 Jun 06;12:114
pubmed: 26048578
Immunol Rev. 2008 Dec;226:205-18
pubmed: 19161426
Brain Res. 2002 Dec 6;957(1):37-41
pubmed: 12443977
Cereb Cortex. 2015 Sep;25(9):2346-53
pubmed: 24610120
Nat Rev Neurosci. 2015 Jun;16(6):358-72
pubmed: 25991443
Biochem Biophys Res Commun. 2019 Oct 20;518(3):486-491
pubmed: 31434608
Cell. 2014 Dec 4;159(6):1327-40
pubmed: 25480297
J Neuroimmunol. 2017 Feb 15;303:90-98
pubmed: 28087076
Neurosci Lett. 2009 Sep 18;461(2):150-4
pubmed: 19539714
Immunity. 2020 Nov 17;53(5):1033-1049.e7
pubmed: 33049219
Nature. 2006 Apr 20;440(7087):1054-9
pubmed: 16547515
Clin Neurophysiol. 2015 Oct;126(10):1847-68
pubmed: 25534482
J Neuroimmunol. 2014 Mar 15;268(1-2):1-12
pubmed: 24529856
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Apr 5;42:115-21
pubmed: 22192886
Glia. 2012 Feb;60(2):306-21
pubmed: 22072381
PLoS One. 2012;7(3):e32883
pubmed: 22403720
J Neurosci. 2005 Mar 23;25(12):3219-28
pubmed: 15788779
Neuroscientist. 2017 Feb;23(1):82-94
pubmed: 26643579
Crit Rev Immunol. 2012;32(1):23-63
pubmed: 22428854
Sci Rep. 2015 Aug 06;5:12726
pubmed: 26246237
Exp Neurol. 2014 Nov;261:230-5
pubmed: 24837317
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Int J Mol Sci. 2020 Sep 23;21(19):
pubmed: 32977401
Glia. 2013 Jan;61(1):24-36
pubmed: 22829357
Trends Pharmacol Sci. 2008 Aug;29(8):402-12
pubmed: 18617277
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Trends Neurosci. 2012 Oct;35(10):638-47
pubmed: 22749718
PLoS Med. 2009 Jul;6(7):e1000113
pubmed: 19636355
Neuron. 2015 Feb 4;85(3):519-33
pubmed: 25619653
J Biol Chem. 2001 Dec 7;276(49):45564-72
pubmed: 11581275
J Neuroinflammation. 2016 Jun 14;13(1):150
pubmed: 27301743
Exp Physiol. 2005 Sep;90(5):663-70
pubmed: 15944202
Int J Mol Sci. 2019 Jul 09;20(13):
pubmed: 31324059
Brain Stimul. 2008 Jul;1(3):164-82
pubmed: 20633383
Alcohol Clin Exp Res. 2015 May;39(5):827-35
pubmed: 25845566
J Neurosci. 2015 Mar 25;35(12):4942-52
pubmed: 25810524
J Neurochem. 2004 Feb;88(3):635-46
pubmed: 14720213
J Neurosci. 2011 May 18;31(20):7521-6
pubmed: 21593336
Brain Res Brain Res Protoc. 1999 Jan;3(3):278-90
pubmed: 9974143
Bull Exp Biol Med. 2019 May;167(1):53-56
pubmed: 31183657
Transl Neurodegener. 2016 Apr 05;5:7
pubmed: 27054030
J Neuroinflammation. 2016 Nov 24;13(1):297
pubmed: 27881137
Neuroimmunomodulation. 2009 Jan;16(1):1-12
pubmed: 19077440
J Neurosci. 2012 Nov 28;32(48):17514-23
pubmed: 23197741
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
Neural Plast. 2018 May 14;2018:8430123
pubmed: 29861718
Mol Med Rep. 2016 Apr;13(4):3391-6
pubmed: 26935478
Front Immunol. 2014 Jul 10;5:316
pubmed: 25071777
Nat Immunol. 2020 Jul;21(7):802-815
pubmed: 32541832
Cell Rep. 2013 Jul 25;4(2):385-401
pubmed: 23850290
J Neurochem. 1999 Apr;72(4):1466-71
pubmed: 10098850
Rev Neurosci. 2004;15(4):253-66
pubmed: 15526550
Neuropharmacology. 2014 Mar;78:13-22
pubmed: 23774138
Neurochem Int. 2013 Jan;62(1):84-91
pubmed: 23201339
Glia. 2005 Oct;52(1):78-84
pubmed: 15920727
Lancet. 1985 May 11;1(8437):1106-7
pubmed: 2860322
Semin Cell Dev Biol. 2019 Oct;94:138-151
pubmed: 31112798
Neuron. 2015 Feb 4;85(3):450-2
pubmed: 25654250